{"id":"W1977103726","doi":"10.1073/pnas.1210353110","title":"Met synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer","year":2013,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; McGill University; St. Michael's Hospital; McGill University Health Centre","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Cancer research; Claudin; Biology; Breast cancer; Cancer; Phenotype; Pathology; Medicine; Gene; Genetics; Tight junction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004998628,0.0001257264,0.0003033608,0.0002140273,0.00008670174,0.00002432049,0.0005449418,0.00006141204,0.00006058224],"category_scores_gemma":[0.00009464052,0.00006947014,0.00007896184,0.0009598989,0.0006207837,0.0003858223,0.0001275214,0.0001692121,8.640135e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005069911,"about_ca_system_score_gemma":0.0001449021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002849497,"about_ca_topic_score_gemma":0.000001088665,"domain_scores_codex":[0.9979147,0.000004417573,0.0002494506,0.0002619111,0.001381571,0.000187903],"domain_scores_gemma":[0.9988162,0.00005870946,0.0003892532,0.00001628088,0.0006259347,0.00009364595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002726797,0.0002093705,0.09271653,0.0008279588,0.0001861567,1.086494e-7,0.0007022834,0.000116931,0.8713297,0.01510614,0.008472622,0.01005958],"study_design_scores_gemma":[0.0002839345,0.00009379669,0.5053967,0.0005543761,0.00004194213,0.00006090182,0.000352621,0.00001087237,0.4916589,0.001354094,0.0001121261,0.00007974853],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799189,0.0003683138,7.240521e-7,0.01649335,0.00002372317,0.0003532075,0.00004751709,0.000007542165,0.002786709],"genre_scores_gemma":[0.996263,0.0001191367,0.002131039,0.0008733744,0.00008705772,0.00004124098,1.577346e-7,0.000006632151,0.0004783444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4126801,"threshold_uncertainty_score":0.283291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02803440875099376,"score_gpt":0.3023753729462326,"score_spread":0.2743409641952388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}