{"id":"W1977142694","doi":"10.1021/bi7016969","title":"A Disease State Mutation Unfolds the Parkin Ubiquitin-like Domain","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Parkin; Ubiquitin ligase; Ubiquitin; Mutation; Point mutation; Deubiquitinating enzyme; Ubiquitin-Protein Ligases; Ubiquitin-conjugating enzyme; Protein degradation; Biology; DNA ligase; Biochemistry; Chemistry; Cell biology; Molecular biology; Genetics; Enzyme; Parkinson's disease; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005503317,0.000202073,0.00009861064,0.00001884215,0.0001605531,0.00004341447,0.0002879137,0.0001303771,0.0000472048],"category_scores_gemma":[0.00009144528,0.0001632582,0.0001166947,0.0001092559,0.0001518905,0.000003013708,0.0001187941,0.0001220239,0.00003044815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002547404,"about_ca_system_score_gemma":0.000139246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009268828,"about_ca_topic_score_gemma":0.00001058369,"domain_scores_codex":[0.998719,0.0000419138,0.000245238,0.0003872014,0.00021124,0.0003954358],"domain_scores_gemma":[0.9990407,0.00002574331,0.0001084664,0.0005282817,0.00007424893,0.0002225766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002806903,0.00006284564,0.0009250966,0.00005598947,0.00004347997,0.00005220922,0.00009267023,0.000006595704,0.9900233,0.00006230414,0.004247746,0.004147128],"study_design_scores_gemma":[0.0004126341,0.00005026154,0.001777736,0.00001873615,0.00001754631,0.00003228098,0.0001566691,0.000012276,0.9385384,0.0004549775,0.05828019,0.0002483019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913421,0.001445856,0.002293518,0.0003195686,0.0001561848,0.0002304105,0.00007282603,0.0000367712,0.004102783],"genre_scores_gemma":[0.9952738,0.00004415259,0.0004227298,0.0008033611,0.0004729086,0.00004121013,0.0003306916,0.00002907335,0.002582086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05403245,"threshold_uncertainty_score":0.6657475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008010389762244751,"score_gpt":0.2414526859412059,"score_spread":0.2334422961789612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}