{"id":"W1977142694","doi":"10.1021/bi7016969","title":"A Disease State Mutation Unfolds the Parkin Ubiquitin-like Domain","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Parkin; Ubiquitin ligase; Ubiquitin; Mutation; Point mutation; Deubiquitinating enzyme; Ubiquitin-Protein Ligases; Ubiquitin-conjugating enzyme; Protein degradation; Biology; DNA ligase; Biochemistry; Chemistry; Cell biology; Molecular biology; Genetics; Enzyme; Parkinson's disease; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009503897,0.0003306851,0.0001935923,0.0001261536,0.000138117,0.00010202,0.00008221734,0.0002762661,0.001252708],"category_scores_gemma":[0.0001567803,0.0000763955,0.0001664227,0.0001124478,0.0001668635,0.0001260443,0.0001435558,0.0002234321,0.000348165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001055445,"about_ca_system_score_gemma":0.00007826305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003030635,"about_ca_topic_score_gemma":0.0003108211,"domain_scores_codex":[0.9999386,0.00001198283,0.000005884378,0.00001867909,0.0000166299,0.000008160804],"domain_scores_gemma":[0.999922,0.00001456935,0.00002713719,0.000008457024,0.000008775575,0.00001889002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009512892,0.00004589376,0.001366519,0.000028781,0.00001675253,0.001033188,0.00003954702,0.0001067508,0.994913,0.0001613982,0.0001163426,0.002076738],"study_design_scores_gemma":[0.00006900659,0.001339248,0.03750008,0.0000232448,0.00006365145,0.01384452,0.0001226748,0.002517816,0.9349388,0.0003222806,0.009233214,0.00002533725],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979435,0.0002611433,0.0009870726,0.00005001324,0.00001444573,0.00001000445,0.0001973879,0.0000409507,0.0004956],"genre_scores_gemma":[0.9985915,0.0001189352,0.0004763572,0.00001910278,0.000003082017,0.000005605675,0.0001682318,0.00000802225,0.0006090964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001252708,"threshold_uncertainty_score":0.004190743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008010389762244751,"score_gpt":0.2414526859412059,"score_spread":0.2334422961789612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}