{"id":"W1977144451","doi":"10.1016/j.cmet.2015.02.005","title":"GLP-1R Agonists Promote Normal and Neoplastic Intestinal Growth through Mechanisms Requiring Fgf7","year":2015,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; National Park Service; Merck; Novo Nordisk; Intarcia Therapeutics; Canada Research Chairs; MedImmune; Ariad Pharmaceuticals","keywords":"Glucagon-like peptide-2; Endocrinology; Internal medicine; Receptor; Biology; Fibroblast growth factor; Epidermal growth factor; Intestinal polyp; Incretin; Growth factor; Enteroendocrine cell; Glucagon-like peptide-1; Signal transduction; Cancer research; Cell biology; Endocrine system; Medicine; Hormone; Type 2 diabetes; Peptide; Biochemistry; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001692117,0.0003148024,0.0002474156,0.0003097615,0.0001452745,0.0004395617,0.0001942143,0.0002779393,0.002929757],"category_scores_gemma":[0.000165984,0.0001297679,0.0003005865,0.0001095874,0.0002280361,0.0003835641,0.0003124704,0.0009581672,0.0004288012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002511245,"about_ca_system_score_gemma":0.0002235868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005654244,"about_ca_topic_score_gemma":0.001348129,"domain_scores_codex":[0.9998988,0.00002515038,0.000005651008,0.00001045516,0.00002910398,0.000030852],"domain_scores_gemma":[0.9999018,0.00002394707,0.00002065339,0.000009695792,0.00001247014,0.00003145892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002580992,0.0003382811,0.000702484,0.0001885672,0.00002476761,0.0002013566,0.00004706641,0.0002337855,0.9608804,0.0007871061,0.0007285399,0.03328676],"study_design_scores_gemma":[0.0004218297,0.003916277,0.01756177,0.0000539664,0.00008082626,0.0005405414,0.0002880716,0.001180462,0.9553527,0.0004843396,0.02009889,0.00002033772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761294,0.00993215,0.002111134,0.0009155323,0.0001989216,0.00005378548,0.0003787915,0.0002384442,0.01004182],"genre_scores_gemma":[0.9907553,0.003563043,0.001645769,0.0001500379,0.00004222068,0.00003689809,0.0002876902,0.00003157988,0.003487636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002929757,"threshold_uncertainty_score":0.009800971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02251234586518604,"score_gpt":0.243852383578982,"score_spread":0.221340037713796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}