{"id":"W1977213462","doi":"10.1002/ardp.200800028","title":"Syntheses and Cytotoxic Properties of the Curcumin Analogs 2,6‐Bis(benzylidene)‐4‐phenylcyclohexanones","year":2008,"lang":"en","type":"article","venue":"Archiv der Pharmazie","topic":"Curcumin's Biomedical Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Cytotoxicity; Curcumin; Stereochemistry; Chemistry; L1210 cells; In vitro; MTT assay; Tubulin; Cell culture; Structure–activity relationship; Chemical synthesis; Microtubule; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008911873,0.0002914826,0.0002648763,0.0001864816,0.0001382045,0.0001464102,0.000163068,0.0001314454,0.002673829],"category_scores_gemma":[0.0001766383,0.0001376261,0.0001209717,0.0002143353,0.0001578864,0.0001738592,0.000107195,0.0002783009,0.0005765697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002409942,"about_ca_system_score_gemma":0.0002922369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005634315,"about_ca_topic_score_gemma":0.001472405,"domain_scores_codex":[0.9999416,0.0000125032,0.000007528022,0.00001148596,0.00001403847,0.00001282721],"domain_scores_gemma":[0.9998983,0.00002082563,0.00003300227,0.00001454501,0.00001636251,0.00001695797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00037262,0.00007332566,0.0002724096,0.0003016973,0.00001336783,0.000242857,0.00005363203,0.00139723,0.9842228,0.0002481708,0.0001428481,0.01265898],"study_design_scores_gemma":[0.00009416401,0.001558479,0.002267563,0.00002564196,0.00004972384,0.0003797435,0.00004360946,0.0003647964,0.9846271,0.00008956088,0.0104824,0.00001727154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977511,0.008327683,0.004066125,0.0001558394,0.00005759383,0.0001829192,0.001172039,0.0001117802,0.00841493],"genre_scores_gemma":[0.9805493,0.008144123,0.005616042,0.00007862337,0.00002763546,0.0001728371,0.001202434,0.00002670577,0.004182368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002673829,"threshold_uncertainty_score":0.008944869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02935608395003738,"score_gpt":0.2392853495441328,"score_spread":0.2099292655940954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}