{"id":"W1977216407","doi":"10.1021/jm000065c","title":"Hunting the Emesis and Efficacy Targets of PDE4 Inhibitors:  Identification of the Photoaffinity Probe 8-(3-Azidophenyl)-6- [(4-iodo-1<i>H</i>-1-imidazolyl)methyl]quinoline (APIIMQ)","year":2000,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Citation; Quinoline; Identification (biology); Library science; Computer science; Chemistry; Information retrieval; Medicine; Psychology; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003906724,0.0003934134,0.000343008,0.0004521316,0.0003641972,0.0004572187,0.0005911413,0.0007223213,0.03252641],"category_scores_gemma":[0.0003800345,0.000340789,0.0004222311,0.0002652832,0.0002721157,0.000502122,0.000416944,0.00111774,0.01126008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006870073,"about_ca_system_score_gemma":0.0003443788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001196551,"about_ca_topic_score_gemma":0.001654402,"domain_scores_codex":[0.9997959,0.00002251866,0.000006309046,0.00003090825,0.00009145193,0.00005304985],"domain_scores_gemma":[0.9998479,0.00002886793,0.0000297251,0.00002025124,0.00003815559,0.0000351765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003595189,0.00008656178,0.0003539879,0.000205309,0.00001556962,0.0002206185,0.00005136516,0.0001790717,0.9504262,0.002176675,0.01299529,0.03292993],"study_design_scores_gemma":[0.00009009489,0.0007430186,0.005086511,0.00003207681,0.00003128559,0.001044915,0.00006540138,0.001490308,0.9024178,0.0007685593,0.08819963,0.00003048674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5789622,0.05627887,0.1022596,0.02032918,0.003389048,0.001333885,0.005576055,0.002801906,0.2290693],"genre_scores_gemma":[0.6777379,0.02105153,0.02384896,0.003553325,0.0006892754,0.0003689954,0.004075323,0.0003259737,0.2683488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03252641,"threshold_uncertainty_score":0.1088117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006149263262642144,"score_gpt":0.2282088440836388,"score_spread":0.2220595808209966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}