{"id":"W1977216407","doi":"10.1021/jm000065c","title":"Hunting the Emesis and Efficacy Targets of PDE4 Inhibitors:  Identification of the Photoaffinity Probe 8-(3-Azidophenyl)-6- [(4-iodo-1<i>H</i>-1-imidazolyl)methyl]quinoline (APIIMQ)","year":2000,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Citation; Quinoline; Identification (biology); Library science; Computer science; Chemistry; Information retrieval; Medicine; Psychology; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007624116,0.000136669,0.0002337778,0.00002239181,0.0001032431,0.00001198524,0.0002436727,0.000136609,0.00007985035],"category_scores_gemma":[0.0003749513,0.00008091054,0.0001595794,0.0001426597,0.0002842262,0.00001104621,0.00005313637,0.0002281225,3.982142e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001593192,"about_ca_system_score_gemma":0.0001131682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007809307,"about_ca_topic_score_gemma":0.000001696489,"domain_scores_codex":[0.998515,0.00007076324,0.0007602303,0.0001499648,0.0003737162,0.0001303867],"domain_scores_gemma":[0.9984621,0.00005438912,0.0008654084,0.0002822102,0.0002701686,0.00006573077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002548219,0.0001055877,0.002016116,0.0001183731,0.00007583991,0.000001004685,0.0002012661,0.0001056025,0.9913055,0.000001126097,0.0006132757,0.005201492],"study_design_scores_gemma":[0.0009129602,0.00009163851,0.02081603,0.0001705075,0.0001007896,0.0001060109,0.0002588875,0.00004117888,0.9734238,0.00003050565,0.003966903,0.00008076203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957118,0.002815198,0.0000995178,0.0007941826,0.0001947999,0.0001140423,0.000006844968,0.000002672265,0.0002609619],"genre_scores_gemma":[0.9983005,0.000553478,0.00008073472,0.00009304249,0.0005444779,0.000002247621,0.000009457236,0.0000110077,0.0004050584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01879991,"threshold_uncertainty_score":0.3299436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006149263262642144,"score_gpt":0.2282088440836388,"score_spread":0.2220595808209966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}