{"id":"W1977219169","doi":"10.1089/vim.2006.19.409","title":"Differential Regulation of CXCR4 and CCR5 Expression by Interleukin (IL)-4 and IL-13 Is Associated with Inhibition of Chemotaxis and Human Immunodeficiency Virus (HIV) Type 1 Replication But Not HIV Entry into Human Monocytes","year":2006,"lang":"en","type":"article","venue":"Viral Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital; Children's Hospital of Eastern Ontario","funders":"","keywords":"Chemokine; Biology; CXCR4; Chemokine receptor; Viral replication; Chemokine receptor CCR5; Cytokine; Viral entry; Virus; Downregulation and upregulation; Virology; Chemotaxis; Receptor; Immunology; Cell biology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001921123,0.0002732122,0.0002623131,0.000135028,0.0001288332,0.0002325724,0.0001511327,0.0002193082,0.001282076],"category_scores_gemma":[0.0001502179,0.000140373,0.0003372068,0.0001337979,0.0002121924,0.0001127077,0.0001502959,0.0005186798,0.0002646203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002235506,"about_ca_system_score_gemma":0.0003569199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007942939,"about_ca_topic_score_gemma":0.001253625,"domain_scores_codex":[0.9996138,0.00007995863,0.00003678355,0.00003424019,0.00007317543,0.0001620401],"domain_scores_gemma":[0.9999061,0.00002460359,0.00002665817,0.000009761167,0.00001360822,0.00001924818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003660583,0.00007464235,0.0004265411,0.00007526345,0.000007436175,0.00005990868,0.00001758556,0.00005884039,0.9965276,0.00009684611,0.00005822213,0.002231007],"study_design_scores_gemma":[0.00008743826,0.002150623,0.02898945,0.00002257085,0.00005380994,0.000562822,0.00006591091,0.001001449,0.9625891,0.00004976559,0.004416729,0.00001024991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992849,0.004255078,0.001312708,0.00009465809,0.00004896702,0.00005119597,0.0002149859,0.00002193944,0.001151426],"genre_scores_gemma":[0.9927768,0.002311762,0.001902633,0.00009615257,0.00002107642,0.00008650311,0.0005137028,0.000004769929,0.002286729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001282076,"threshold_uncertainty_score":0.004288912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009028242002881099,"score_gpt":0.2418545128370577,"score_spread":0.2328262708341766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}