{"id":"W1977219169","doi":"10.1089/vim.2006.19.409","title":"Differential Regulation of CXCR4 and CCR5 Expression by Interleukin (IL)-4 and IL-13 Is Associated with Inhibition of Chemotaxis and Human Immunodeficiency Virus (HIV) Type 1 Replication But Not HIV Entry into Human Monocytes","year":2006,"lang":"en","type":"article","venue":"Viral Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Ottawa Hospital; Children's Hospital of Eastern Ontario","funders":"","keywords":"Chemokine; Biology; CXCR4; Chemokine receptor; Viral replication; Chemokine receptor CCR5; Cytokine; Viral entry; Virus; Downregulation and upregulation; Virology; Chemotaxis; Receptor; Immunology; Cell biology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001189524,0.0001996883,0.0003656342,0.0001621592,0.0002415134,0.00001589045,0.00008251108,0.0002919915,0.0001201926],"category_scores_gemma":[0.00003535649,0.0001666117,0.00003261016,0.00009033211,0.0007494664,0.0001359028,0.0001455326,0.0001948022,0.000009616567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000596558,"about_ca_system_score_gemma":0.00001790752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001553117,"about_ca_topic_score_gemma":0.00008138011,"domain_scores_codex":[0.9986549,0.0001894476,0.0004350814,0.0004117392,0.00005766575,0.0002511363],"domain_scores_gemma":[0.99916,0.00006486993,0.0003368208,0.0003095255,0.0001130673,0.00001570792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005918785,0.0003556127,0.007867331,0.00002589027,0.0001378091,0.000001073181,0.0004523905,2.207339e-7,0.9880202,0.0002782877,0.0003912966,0.001878027],"study_design_scores_gemma":[0.002626487,0.001160435,0.1365404,0.00007858222,0.00004566568,0.0000160675,0.0001152451,0.000005958863,0.8587621,0.0003817532,0.0001396767,0.0001276022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971921,0.001972095,0.00006577413,0.00008620542,0.00002787568,0.0002937458,0.0002148384,0.0000303538,0.0001169776],"genre_scores_gemma":[0.9971724,0.000189422,0.0000359642,0.000008448399,0.000006626539,0.00002435042,0.001725649,0.00001539145,0.0008217661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1292581,"threshold_uncertainty_score":0.6794226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009028242002881099,"score_gpt":0.2418545128370577,"score_spread":0.2328262708341766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}