{"id":"W1977219542","doi":"10.1021/bi700602n","title":"Mechanism of a GatCAB Amidotransferase:  Aspartyl-tRNA Synthetase Increases Its Affinity for Asp-tRNA<sup>Asn</sup> and Novel Aminoacyl-tRNA Analogues Are Competitive Inhibitors","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Glutamine amidotransferase; Transfer RNA; Biochemistry; Aminoacyl-tRNA; Enzyme; Archaea; Bacteria; Aminoacyl tRNA synthetase; Biology; Chemistry; RNA; Amino acid; Genetics; Glutamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003052002,0.0006822987,0.0008549604,0.0001677095,0.0002281203,0.0004484859,0.0007470228,0.0006603046,0.001793883],"category_scores_gemma":[0.0001820285,0.0003738161,0.000354629,0.0001073994,0.0003818426,0.0003481997,0.0003254005,0.0005844672,0.0008690701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007959214,"about_ca_system_score_gemma":0.0003295028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001363485,"about_ca_topic_score_gemma":0.0009238815,"domain_scores_codex":[0.9997767,0.00003922446,0.00001773524,0.00005540611,0.00006395787,0.00004700893],"domain_scores_gemma":[0.9998839,0.00002412785,0.00002566246,0.000009887574,0.00002631142,0.00003010217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003926326,0.00006947165,0.0002989109,0.0001885826,0.00002730309,0.0001627189,0.00003543352,0.000298215,0.9940705,0.000613291,0.0001319827,0.003711066],"study_design_scores_gemma":[0.00008524046,0.000528059,0.002353303,0.000009159956,0.00002686628,0.001072196,0.00002644477,0.005446239,0.9860617,0.0001279262,0.004247192,0.00001566939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9593806,0.01345619,0.01983353,0.0006202826,0.0001651154,0.0003243895,0.0002706326,0.0005575602,0.005391715],"genre_scores_gemma":[0.9927081,0.001526742,0.002674151,0.00009609569,0.00001661911,0.00006118808,0.0001377344,0.00002429214,0.002755029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001793883,"threshold_uncertainty_score":0.006001174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01515526779992728,"score_gpt":0.2400419372418028,"score_spread":0.2248866694418755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}