{"id":"W1977219542","doi":"10.1021/bi700602n","title":"Mechanism of a GatCAB Amidotransferase:  Aspartyl-tRNA Synthetase Increases Its Affinity for Asp-tRNA<sup>Asn</sup> and Novel Aminoacyl-tRNA Analogues Are Competitive Inhibitors","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Glutamine amidotransferase; Transfer RNA; Biochemistry; Aminoacyl-tRNA; Enzyme; Archaea; Bacteria; Aminoacyl tRNA synthetase; Biology; Chemistry; RNA; Amino acid; Genetics; Glutamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007640064,0.0005374777,0.0005823135,0.00009714772,0.0002016154,0.00004634666,0.000379205,0.0005858642,0.00004682442],"category_scores_gemma":[0.0006583646,0.0005398066,0.000299887,0.0001620884,0.0002428368,0.00001640887,0.0001651804,0.0001797313,0.000004337619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000372597,"about_ca_system_score_gemma":0.0001461543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000553118,"about_ca_topic_score_gemma":0.00003702802,"domain_scores_codex":[0.9974394,0.00006911493,0.0006526001,0.0008787254,0.0003379486,0.0006221503],"domain_scores_gemma":[0.9981752,0.0001963768,0.0003487921,0.0005894896,0.0003369658,0.0003531485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005182187,0.0003951454,0.0002375746,0.0004015852,0.0001964491,0.00001530429,0.00005056929,0.000007422374,0.9959983,0.001135841,0.0002371068,0.0008064609],"study_design_scores_gemma":[0.001318593,0.000358385,0.0002635317,0.0002784446,0.0001409371,0.000067189,0.0008485994,0.00006295377,0.9947778,0.0002534114,0.001026858,0.000603308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852366,0.002015255,0.00916725,0.00009756361,0.0001000343,0.0006570724,0.00207187,0.00004645813,0.0006079253],"genre_scores_gemma":[0.995787,0.0002975339,0.002366014,0.000162154,0.0004931795,0.00008110083,0.0004595659,0.00007099765,0.0002824417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01055044,"threshold_uncertainty_score":0.9997054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01515526779992728,"score_gpt":0.2400419372418028,"score_spread":0.2248866694418755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}