{"id":"W1977234608","doi":"10.1021/ml1002663","title":"Peptide-Chlorambucil Conjugates Combat Pgp-Dependent Drug Efflux","year":2011,"lang":"ca","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Efflux; Drug; Pharmacology; Toxicity; Chlorambucil; Pharmacokinetics; P-glycoprotein; Drug resistance; Multiple drug resistance; Chemistry; Doxorubicin; Medicine; Biology; Biochemistry; Chemotherapy; Internal medicine; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001696181,0.0003838234,0.0003692581,0.000194978,0.000135645,0.0002297751,0.0002115993,0.0003002929,0.0004875354],"category_scores_gemma":[0.000160813,0.0001259811,0.0001414517,0.0001259,0.0002031169,0.0002652751,0.0001926209,0.0004786024,0.0001693113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002222131,"about_ca_system_score_gemma":0.000147541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002047615,"about_ca_topic_score_gemma":0.0005154462,"domain_scores_codex":[0.9998599,0.00003661276,0.00001251254,0.00002092548,0.00003671486,0.00003326326],"domain_scores_gemma":[0.9999121,0.00001489919,0.00003068159,0.000009700017,0.00001291031,0.00001970023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001522597,0.00004562637,0.0001550367,0.00005344131,0.000009097788,0.00005248033,0.00001791819,0.0002700519,0.9911057,0.0001392064,0.00008844506,0.007910703],"study_design_scores_gemma":[0.00006261581,0.001707643,0.001045406,0.00000424212,0.00001807421,0.0005005177,0.000006047482,0.0006308088,0.9922612,0.00002818563,0.003728108,0.000007163457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877645,0.006698406,0.003350774,0.0001587572,0.00003005283,0.00007076394,0.00009697259,0.00006673611,0.001763027],"genre_scores_gemma":[0.9933131,0.002086557,0.003505329,0.00006658962,0.00001840949,0.00002660966,0.0001207713,0.00001049567,0.0008520448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004875354,"threshold_uncertainty_score":0.001630962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0171663695762953,"score_gpt":0.2163120157932341,"score_spread":0.1991456462169388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}