{"id":"W1977234970","doi":"10.1074/jbc.m306589200","title":"Palmitoylation of the V2 Vasopressin Receptor Carboxyl Tail Enhances β-Arrestin Recruitment Leading to Efficient Receptor Endocytosis and ERK1/2 Activation","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Palmitoylation; Cell biology; G protein-coupled receptor kinase; G protein-coupled receptor; Arrestin; Protein kinase A; Biology; Endocytosis; Arginine vasopressin receptor 2; Enzyme-linked receptor; Tropomyosin receptor kinase C; Receptor; Chemistry; Biochemistry; Signal transduction; Phosphorylation; Cysteine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004885916,0.0001526172,0.0002348392,0.00002010173,0.00008547671,0.00002144428,0.0001782348,0.0001998249,0.0001435492],"category_scores_gemma":[0.0007748718,0.00009560027,0.0001293725,0.0001151368,0.00006492087,0.000004767402,0.00006152355,0.0001650668,9.710009e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004238583,"about_ca_system_score_gemma":0.00006070108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001764764,"about_ca_topic_score_gemma":2.005732e-7,"domain_scores_codex":[0.9988411,0.0001195224,0.0004356188,0.0002273447,0.0001994401,0.0001769594],"domain_scores_gemma":[0.9990687,0.00005866186,0.0004539051,0.000154996,0.0001584692,0.0001052473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009678074,0.00005495484,0.001083425,0.00001953362,0.00003308801,2.693394e-7,0.00004893049,0.0003017396,0.9964296,0.00001443184,0.0002031574,0.001714105],"study_design_scores_gemma":[0.0002784978,0.0002360079,0.0002782881,0.000113907,0.00001350377,0.00001194329,0.0001751445,0.00000935341,0.9908051,0.00003707666,0.007922942,0.0001182602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972405,0.0005562028,0.001397568,0.0001284482,0.0002199657,0.0001690007,0.000006666745,0.000003290157,0.0002783817],"genre_scores_gemma":[0.9968504,0.000190289,0.002540303,0.00005764448,0.0002232311,0.00001220909,0.000007168996,0.000008838869,0.0001099551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007719785,"threshold_uncertainty_score":0.3898466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03637800201888351,"score_gpt":0.2725536818245723,"score_spread":0.2361756798056888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}