{"id":"W1977234970","doi":"10.1074/jbc.m306589200","title":"Palmitoylation of the V2 Vasopressin Receptor Carboxyl Tail Enhances β-Arrestin Recruitment Leading to Efficient Receptor Endocytosis and ERK1/2 Activation","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Palmitoylation; Cell biology; G protein-coupled receptor kinase; G protein-coupled receptor; Arrestin; Protein kinase A; Biology; Endocytosis; Arginine vasopressin receptor 2; Enzyme-linked receptor; Tropomyosin receptor kinase C; Receptor; Chemistry; Biochemistry; Signal transduction; Phosphorylation; Cysteine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008923898,0.0003133594,0.0002673688,0.0000891263,0.0001440075,0.000272409,0.0001229772,0.0001696849,0.001293593],"category_scores_gemma":[0.00008464759,0.0001236272,0.0002621823,0.00007119937,0.000155152,0.000193382,0.0001996634,0.0004932061,0.0003958493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002675512,"about_ca_system_score_gemma":0.0001562488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004207077,"about_ca_topic_score_gemma":0.0006172704,"domain_scores_codex":[0.9999017,0.00001516236,0.0000101359,0.00002218783,0.00001963193,0.00003113311],"domain_scores_gemma":[0.9999454,0.000008830222,0.00001645769,0.000005673699,0.000006629071,0.00001700532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008966327,0.000009745939,0.00004006904,0.00001813503,0.000003993363,0.00001314129,0.000005666606,0.00002984132,0.9994424,0.00003474751,0.00001542139,0.0002971175],"study_design_scores_gemma":[0.00001185573,0.00009553324,0.001645568,0.000002945407,0.000007279956,0.0001052173,0.00001203503,0.000571669,0.9963441,0.00002023175,0.001180234,0.000003235906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965934,0.0007732791,0.001494142,0.0000687264,0.00001719736,0.0000175058,0.0001734187,0.00003556951,0.0008267274],"genre_scores_gemma":[0.9955909,0.0007914536,0.001147919,0.00006609472,0.00001013079,0.00002429635,0.0003675999,0.00002222998,0.001979453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001293593,"threshold_uncertainty_score":0.004327536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03637800201888351,"score_gpt":0.2725536818245723,"score_spread":0.2361756798056888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}