{"id":"W1977260466","doi":"10.1016/j.jconrel.2012.07.043","title":"A docetaxel-carboxymethylcellulose nanoparticle outperforms the approved taxane nanoformulation, Abraxane, in mouse tumor models with significant control of metastases","year":2012,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":94,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; Ontario Ministry of Economic Development and Innovation; Ontario Centres of Excellence","keywords":"Docetaxel; Taxane; Paclitaxel; Pharmacology; Medicine; Spleen; Melanoma; Chemistry; Cancer; Internal medicine; Cancer research; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00438642,0.0003419331,0.001255815,0.0002882598,0.0001265311,0.00008393497,0.00049348,0.00006928285,0.0001204611],"category_scores_gemma":[0.0007441984,0.0001783882,0.0003049448,0.0004385932,0.0002634099,0.00132619,0.00004335797,0.0003240831,0.00002009537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001180211,"about_ca_system_score_gemma":0.0004104315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001001573,"about_ca_topic_score_gemma":0.00002537197,"domain_scores_codex":[0.9954813,0.0007235478,0.001805851,0.0002259007,0.001015904,0.0007474666],"domain_scores_gemma":[0.9955191,0.0009747631,0.001962115,0.0005120707,0.0006553548,0.0003766067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01459524,0.001158619,0.001586921,0.00003852765,0.0001417032,0.00005811084,0.0005581439,0.05919024,0.9216349,0.0007603263,0.00005200011,0.0002252567],"study_design_scores_gemma":[0.03897617,0.0009091519,0.0003204755,0.00009244667,0.0005111993,0.0000958193,0.0007467803,0.05214398,0.9055729,0.0002547055,0.00006744258,0.000308956],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914674,0.001984429,0.004607839,0.0004947003,0.0001998944,0.001117621,0.00005653383,0.00002223424,0.00004937046],"genre_scores_gemma":[0.9981936,0.00002665868,0.001152865,0.000287229,0.0001530313,0.00006491285,0.000001130639,0.00003910472,0.00008149575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02438092,"threshold_uncertainty_score":0.7274461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01151867135566043,"score_gpt":0.2172481835447421,"score_spread":0.2057295121890817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}