{"id":"W1977306646","doi":"10.1038/sj.onc.1208173","title":"Multisite protein modification and intramolecular signaling","year":2004,"lang":"en","type":"review","venue":"Oncogene","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":263,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Cancer Institute","keywords":"Biology; SUMO protein; Cell biology; Bromodomain; Ubiquitin; Adapter molecule crk; Signal transducing adaptor protein; Chromodomain; Phosphorylation; Signal transduction; SH2 domain; Histone; Acetylation; Biochemistry; Genetics; Tyrosine phosphorylation; RNA; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008722479,0.001850274,0.002304688,0.001823355,0.0005803215,0.001722018,0.002485509,0.002439375,0.00259498],"category_scores_gemma":[0.0004573665,0.0006650279,0.0004483654,0.002920019,0.001463325,0.002702875,0.0008482352,0.003160207,0.003462774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001196642,"about_ca_system_score_gemma":0.0008158626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007711819,"about_ca_topic_score_gemma":0.001669863,"domain_scores_codex":[0.9997789,0.00002955205,0.00002468978,0.00005565721,0.00007332682,0.00003791383],"domain_scores_gemma":[0.9998123,0.00007457857,0.00002282637,0.00001564914,0.00004973247,0.00002493345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002297355,0.0001633669,0.0001666491,0.007682831,0.0001080848,0.0008732879,0.00007669862,0.0009541161,0.01069219,0.01669177,0.05866673,0.9036946],"study_design_scores_gemma":[0.00002704746,0.00004877085,0.0003132552,0.0004828902,0.00006881743,0.001745684,0.0000451596,0.0001825757,0.002743624,0.00510959,0.9892139,0.00001870879],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002023105,0.9958307,0.00097432,0.0002969142,0.0008124958,0.00000756136,0.00001526259,0.00002419012,0.001836246],"genre_scores_gemma":[0.001542037,0.9939172,0.0007615747,0.0003328543,0.0005886478,0.00001820279,0.00004602543,0.000003610189,0.00278981],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00259498,"threshold_uncertainty_score":0.008682251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.037981074083204,"score_gpt":0.3152293485613293,"score_spread":0.2772482744781253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}