{"id":"W1977306646","doi":"10.1038/sj.onc.1208173","title":"Multisite protein modification and intramolecular signaling","year":2004,"lang":"en","type":"review","venue":"Oncogene","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":263,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Cancer Institute","keywords":"Biology; SUMO protein; Cell biology; Bromodomain; Ubiquitin; Adapter molecule crk; Signal transducing adaptor protein; Chromodomain; Phosphorylation; Signal transduction; SH2 domain; Histone; Acetylation; Biochemistry; Genetics; Tyrosine phosphorylation; RNA; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001936692,0.0003300741,0.000503924,0.000060689,0.00007687737,0.00004274777,0.0001867546,0.0004539692,0.00001484155],"category_scores_gemma":[0.0000492252,0.0003028859,0.0001977744,0.00009320971,0.00005726148,0.000002008591,0.0001121496,0.0001690285,0.0000357179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003569509,"about_ca_system_score_gemma":0.0001686257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000138922,"about_ca_topic_score_gemma":0.000002730286,"domain_scores_codex":[0.998661,0.0001170387,0.0003207176,0.0005496481,0.0001181945,0.0002333826],"domain_scores_gemma":[0.9992409,0.000005979681,0.0002006055,0.0003953975,0.00004732384,0.0001098363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000005477004,0.00003302484,2.896523e-7,0.004727999,0.00009210977,0.00001144418,0.00001141508,0.000003160555,0.1454974,0.0001131846,0.00001381717,0.8494907],"study_design_scores_gemma":[0.0002093263,0.00009973238,1.096797e-7,0.003055401,0.0001403317,0.00005828722,0.000002686429,0.000002079543,0.1001586,0.00006406938,0.8958452,0.0003641576],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001027121,0.9958047,0.00164643,0.000008498469,0.00004576277,0.001071848,0.00006376579,0.00001943749,0.0003123852],"genre_scores_gemma":[0.0007961934,0.9937952,0.003648784,0.00003031352,0.0002959551,0.0003076459,0.0007464914,0.00007110823,0.0003083102],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8958314,"threshold_uncertainty_score":0.9999423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.037981074083204,"score_gpt":0.3152293485613293,"score_spread":0.2772482744781253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}