{"id":"W1977337614","doi":"10.1128/aac.44.3.783-786.2000","title":"Antiviral Activity of 2′-Deoxy-3′-Oxa-4′-Thiocytidine (BCH-10652) against Lamivudine-Resistant Human Immunodeficiency Virus Type 1 in SCID-hu Thy/Liv Mice","year":2000,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"BioPhage Pharma (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Elizabeth Glaser Pediatric AIDS Foundation","keywords":"Lamivudine; Virology; Resistance mutation; In vivo; Reverse transcriptase; Biology; Severe combined immunodeficiency; Virus; clone (Java method); Viral replication; Nucleoside analogue; Nucleotidyltransferase; Zidovudine; Nucleoside; Viral disease; Hepatitis B virus; RNA; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002035835,0.0004677213,0.0004393302,0.0003854759,0.0001731552,0.0002278162,0.0003111597,0.000467769,0.001181126],"category_scores_gemma":[0.0001623531,0.000231538,0.0002544039,0.0001565326,0.0002653616,0.0001505442,0.00007439146,0.0006334453,0.0003659938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002753419,"about_ca_system_score_gemma":0.0002728683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001448406,"about_ca_topic_score_gemma":0.001592633,"domain_scores_codex":[0.9998228,0.00004324303,0.00001303337,0.00003028513,0.00003633307,0.000054325],"domain_scores_gemma":[0.9998013,0.00004776273,0.00005510495,0.00002384451,0.00001675699,0.00005520773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003084249,0.00005771394,0.00009268016,0.0000342843,0.000005949991,0.00002268136,0.00001128421,0.0001032386,0.9978764,0.00004640183,0.00003766284,0.001403174],"study_design_scores_gemma":[0.00008782736,0.002779838,0.001687894,0.000007556674,0.00002016516,0.0001248767,0.000008871797,0.0005263783,0.9939872,0.00001855259,0.0007455386,0.000005441902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941785,0.002258161,0.0008497736,0.00006820556,0.00004108784,0.0000392944,0.0004573227,0.0001401522,0.001967506],"genre_scores_gemma":[0.9949019,0.00100397,0.001303879,0.00003325106,0.00002126573,0.00003702847,0.0005711342,0.00002437191,0.002103266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001448406,"threshold_uncertainty_score":0.003951252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01547606612426237,"score_gpt":0.2734379883398734,"score_spread":0.257961922215611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}