{"id":"W1977356375","doi":"10.1186/cc8240","title":"The TLR4 antagonist CRX-526 reduces LPS-induced leukocyte activation and improves capillary perfusion of the rat intestine","year":2010,"lang":"en","type":"article","venue":"Critical Care","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Medicine; Antagonist; Perfusion; Pharmacology; TLR4; Anesthesia; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001946898,0.0004870129,0.0006813331,0.0003014751,0.0001773808,0.0002606965,0.0003527275,0.0003886616,0.002214226],"category_scores_gemma":[0.0002262678,0.0002012003,0.000212664,0.0001406683,0.0002994067,0.0003763976,0.0002138449,0.001015812,0.0004426419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001664544,"about_ca_system_score_gemma":0.0003309406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003168393,"about_ca_topic_score_gemma":0.0004615808,"domain_scores_codex":[0.9998721,0.00003137027,0.000009321675,0.00001375996,0.00002257952,0.00005092936],"domain_scores_gemma":[0.9998311,0.00001768542,0.00006013445,0.00001427304,0.00001816645,0.00005856602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004027324,0.0005927698,0.0001838823,0.0001330343,0.00001651494,0.00005778679,0.00001644301,0.0001235399,0.9876229,0.00008266365,0.0001259822,0.007017113],"study_design_scores_gemma":[0.0005434644,0.01169763,0.004525515,0.00002165607,0.00007099454,0.0001725418,0.00005453566,0.0009356634,0.9803538,0.00009570968,0.001514339,0.00001424912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995819,0.002349491,0.0007677111,0.0002021841,0.00004676005,0.00002038425,0.0001110829,0.00008149416,0.000601833],"genre_scores_gemma":[0.9932727,0.002498627,0.00148444,0.0001289497,0.00004884344,0.00005227563,0.0003135695,0.00002279423,0.002177689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002214226,"threshold_uncertainty_score":0.007407308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009721201230495318,"score_gpt":0.2596398686498906,"score_spread":0.2499186674193953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}