{"id":"W1977358562","doi":"10.1016/j.scr.2011.11.001","title":"Self-organizing circuitry and emergent computation in mouse embryonic stem cells","year":2011,"lang":"en","type":"review","venue":"Stem Cell Research","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Biotechnology and Biological Sciences Research Council; European Commission; Wellcome Trust; Lawrence Berkeley National Laboratory; Medical Research Council; Microsoft Research","keywords":"Biology; Cell fate determination; Transcription factor; Embryonic stem cell; Gene regulatory network; Induced pluripotent stem cell; Regulation of gene expression; Computational biology; Stem cell; Cellular differentiation; Context (archaeology); Cell biology; Neuroscience; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003804706,0.0007549411,0.0008173652,0.0008278827,0.0002021479,0.0008349781,0.001092446,0.001071912,0.001108319],"category_scores_gemma":[0.0003947758,0.000330635,0.000256906,0.001088182,0.001120302,0.001377226,0.0005464457,0.00146846,0.001015487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008814815,"about_ca_system_score_gemma":0.0005938279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008658383,"about_ca_topic_score_gemma":0.001651361,"domain_scores_codex":[0.999918,0.00001141111,0.000009957739,0.00002056159,0.00003144041,0.000008597413],"domain_scores_gemma":[0.9998562,0.00007609449,0.0000195994,0.000007785679,0.00002718729,0.00001310909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007154766,0.0000432632,0.0001609652,0.005630108,0.00006053137,0.0002148561,0.00005782994,0.002268467,0.009669331,0.05162809,0.02225188,0.9079431],"study_design_scores_gemma":[0.0000254718,0.00004863662,0.0006713306,0.0009391226,0.00005750733,0.0006450861,0.00003883378,0.0008399123,0.005068699,0.02940906,0.9622203,0.00003599255],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004982185,0.9942644,0.001853675,0.0004913887,0.0003693498,0.000004882965,0.00002001088,0.00002353219,0.002474555],"genre_scores_gemma":[0.003175858,0.9935312,0.0008859384,0.0003332999,0.0003987076,0.00001089123,0.00004118352,0.000004946047,0.001618062],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001108319,"threshold_uncertainty_score":0.006395578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09435540382570334,"score_gpt":0.3556605484630599,"score_spread":0.2613051446373566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}