{"id":"W1977380476","doi":"10.1111/j.0022-202x.2004.22409.x","title":"Expression of Indoleamine 2,3-Dioxygenase in Dermal Fibroblasts Functions as a Local Immunosuppressive Factor","year":2004,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"University of Alberta; Canadian Institutes of Health Research; Hospital for Sick Children; University of Miami","keywords":"Indoleamine 2,3-dioxygenase; Immune system; Propidium iodide; Jurkat cells; Biology; Cell biology; Apoptosis; CD8; Immunology; Cancer research; Programmed cell death; T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006555135,0.0002024553,0.0004767516,0.0004490587,0.00007377033,0.00001373471,0.0003279014,0.0001581376,0.00007364657],"category_scores_gemma":[0.001452433,0.0001659195,0.0001431318,0.0004458667,0.001079287,0.0004360916,0.00009019694,0.0005228447,0.00002903087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007493768,"about_ca_system_score_gemma":0.0004004195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002100723,"about_ca_topic_score_gemma":0.00001738183,"domain_scores_codex":[0.9980418,0.0003426154,0.0007849414,0.0002178809,0.0003075829,0.0003051517],"domain_scores_gemma":[0.9984015,0.0003660137,0.0007394237,0.0001639285,0.0001468367,0.0001822488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002056763,0.0002245814,0.0001773491,0.00003589531,0.00001069714,0.0005167636,0.001995812,0.001513499,0.9941814,0.0007365461,0.0002387052,0.0001630905],"study_design_scores_gemma":[0.002799248,0.0002982183,0.009598102,0.0002661576,0.000003346451,0.002056756,0.001188005,0.0000248616,0.9789791,0.004512778,0.0001328765,0.0001405473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970251,0.0001963795,0.001144494,0.001014701,0.0001560208,0.0001430324,0.00001942641,0.00001223017,0.000288584],"genre_scores_gemma":[0.9987147,0.00002453621,0.0004864897,0.0007051248,0.00002670641,0.000005442695,0.000001575735,0.00001635494,0.000019032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01520228,"threshold_uncertainty_score":0.6766002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02182199340180982,"score_gpt":0.2610927704355813,"score_spread":0.2392707770337714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}