{"id":"W1977392840","doi":"10.1073/pnas.1004368107","title":"Genetic suppression of the circadian <i>Clock</i> mutation by the melatonin biosynthesis pathway","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Sleep & Circadian Network","funders":"National Institutes of Health; National Institute of Mental Health; Howard Hughes Medical Institute","keywords":"Melatonin; Biology; PER2; Circadian clock; Circadian rhythm; Suprachiasmatic nucleus; Endocrinology; Internal medicine; Genetics; Mutant; CLOCK; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001032333,0.0001182917,0.0001409538,0.00009927105,0.0004852639,0.00003521684,0.001522124,0.000124737,0.00003472325],"category_scores_gemma":[0.001890588,0.00005824494,0.0001260468,0.001021317,0.002005206,0.0003100603,0.0001672403,0.0003444587,0.000003530842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000164873,"about_ca_system_score_gemma":0.00007707027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001064505,"about_ca_topic_score_gemma":2.876395e-7,"domain_scores_codex":[0.9976922,0.00002799231,0.0003810322,0.0003092311,0.001382567,0.0002069499],"domain_scores_gemma":[0.9986764,0.0004572506,0.0006473105,0.00003170588,0.0001387978,0.00004856989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004336787,0.00002725715,0.003673951,0.00001674652,0.000002244514,6.1306e-9,0.0003186876,0.00002194237,0.9465402,0.04792871,0.0007271396,0.0007387817],"study_design_scores_gemma":[0.0001010054,0.00001486577,0.06080718,0.00005004859,0.000009751359,0.00003102751,0.00009000126,0.000501884,0.9284785,0.008354446,0.001492503,0.00006873035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890514,0.0001469915,5.689722e-7,0.005558925,0.0001133024,0.0002915938,0.00005104381,0.000009857865,0.004776306],"genre_scores_gemma":[0.9990225,0.00002453361,0.0001472796,0.0005022053,0.00006473184,0.00001313538,4.176654e-8,0.000006815284,0.0002187346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05713323,"threshold_uncertainty_score":0.7388266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02330308878385297,"score_gpt":0.2605429316932117,"score_spread":0.2372398429093588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}