{"id":"W1977403650","doi":"10.1016/j.freeradbiomed.2013.10.810","title":"Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms","year":2013,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Aryl hydrocarbon receptor; Chemistry; Aryl hydrocarbon receptor nuclear translocator; Sulforaphane; Cytochrome P450; Enzyme inducer; NAD+ kinase; Biochemistry; CYP1B1; Transcription factor; Inducer; Enzyme; Molecular biology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001337019,0.0003972847,0.0002660532,0.0003303139,0.0002128123,0.0002961106,0.0001615983,0.0002445327,0.002285922],"category_scores_gemma":[0.000129831,0.0001639639,0.0002125916,0.0002600374,0.0001694309,0.0001927447,0.0002219533,0.0002948,0.0004405771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003219113,"about_ca_system_score_gemma":0.0001503118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000593064,"about_ca_topic_score_gemma":0.001670446,"domain_scores_codex":[0.9998258,0.00003607792,0.000009654413,0.00004211139,0.00005645928,0.00002993878],"domain_scores_gemma":[0.9998753,0.00001581314,0.00002931517,0.0000202712,0.00002978304,0.00002941593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001604647,0.000009091281,0.0002359556,0.00002704786,0.000008720541,0.00003500987,0.000008656795,0.00002288366,0.9977534,0.0001374592,0.00008391298,0.001517383],"study_design_scores_gemma":[0.000006651323,0.0001840515,0.002327909,0.000002813061,0.0000193161,0.0001662225,0.0000240967,0.0001261155,0.9937677,0.0001133876,0.003258268,0.000003411978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733532,0.004923504,0.01174335,0.0004483921,0.0001917308,0.00006102158,0.001538203,0.0005800348,0.007160664],"genre_scores_gemma":[0.9898008,0.001126876,0.002608155,0.00007968409,0.00001525175,0.00001528489,0.0007841052,0.00002484516,0.005544975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002285922,"threshold_uncertainty_score":0.007647216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0132836556841894,"score_gpt":0.2658904211402442,"score_spread":0.2526067654560549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}