{"id":"W1977416347","doi":"10.1038/nmeth.1199","title":"BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals","year":2008,"lang":"en","type":"article","venue":"Nature Methods","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":628,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Human Genome Research Institute; Wellcome Trust","keywords":"Recombineering; Transgene; Biology; Computational biology; Bacterial artificial chromosome; Gene; Genome; Function (biology); Transfection; Molecular biology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007074137,0.0001223336,0.00019075,0.00007201196,0.00002813381,0.000003202684,0.00008564324,0.0003827952,0.000005453869],"category_scores_gemma":[0.000169779,0.0001203479,0.00009319161,0.0001347017,0.00002070122,0.000006475073,0.00001661198,0.0001530147,2.693258e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001054874,"about_ca_system_score_gemma":0.00003894043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001271122,"about_ca_topic_score_gemma":0.00002130353,"domain_scores_codex":[0.9991145,0.0001560845,0.0002350579,0.0002694977,0.00007425305,0.000150625],"domain_scores_gemma":[0.9995813,0.00003836069,0.00005714678,0.0002146417,0.00007944816,0.00002914018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001969089,0.00002811178,0.00002901125,0.00005446594,0.00002495648,4.731765e-7,0.0001031274,0.002065214,0.9663626,0.0004607728,0.00008176775,0.03059261],"study_design_scores_gemma":[0.0006956611,0.0002609814,0.0006199382,0.00001290277,0.00001635359,0.000005367768,0.00003469216,0.0007435076,0.9815168,0.001703592,0.014258,0.0001321739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.09042253,0.00212443,0.9066114,0.00009683042,0.0002100036,0.0004521997,0.0000123887,0.000008872178,0.00006136905],"genre_scores_gemma":[0.3256454,0.00008426188,0.6737539,0.0000479158,0.0001573152,0.0001047493,0.0000509582,0.00001775422,0.0001377556],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.2352229,"threshold_uncertainty_score":0.4907644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02256918009807363,"score_gpt":0.3982031726603523,"score_spread":0.3756339925622787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}