{"id":"W1977416367","doi":"10.1002/anie.200601421","title":"Family 4 Glycosidases Carry Out Efficient Hydrolysis of Thioglycosides by an α,β‐Elimination Mechanism","year":2006,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Glycoside hydrolase; Chemistry; Hydrolysis; Nucleophile; Cleavage (geology); Enzyme; Stereochemistry; Linkage (software); Mechanism (biology); Combinatorial chemistry; Biochemistry; Catalysis; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001543226,0.0002545265,0.0002515014,0.00009824587,0.0000919842,0.00006313398,0.0003217564,0.0002224998,0.001009452],"category_scores_gemma":[0.00009957267,0.0002722508,0.0001951665,0.0001054539,0.00009164326,0.0002553182,0.00005203365,0.0001480222,0.00001463143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002174991,"about_ca_system_score_gemma":0.00003612244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003403284,"about_ca_topic_score_gemma":0.00002036096,"domain_scores_codex":[0.9981506,0.00001446757,0.00049772,0.000432796,0.0006778163,0.0002265294],"domain_scores_gemma":[0.9988529,0.0001335719,0.0003211017,0.000297234,0.0003142885,0.00008088607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006778676,0.0003907324,0.00006567696,0.00005807182,0.00006309287,0.000007116454,0.00009901026,0.0002319532,0.9938076,0.0004810088,0.00437592,0.0003519999],"study_design_scores_gemma":[0.0004636068,0.00001843285,0.00009767107,0.0000883956,0.00008017826,0.000008430866,0.0002586697,0.001726911,0.9937096,0.001899094,0.001379185,0.0002698166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.947387,0.0001587143,0.002215677,0.0003106346,0.0004632759,0.0000612011,0.0009219858,0.0001347363,0.04834674],"genre_scores_gemma":[0.9937739,0.00004050573,0.0001229529,0.00006220888,0.001113727,0.00006028245,0.003634909,0.00003174932,0.001159722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04718702,"threshold_uncertainty_score":0.9999729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01090598670371512,"score_gpt":0.2305714290573129,"score_spread":0.2196654423535978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}