{"id":"W1977441177","doi":"10.1210/jc.2013-1834","title":"Decreased Transcriptional Activity of<i>Calcium-sensing receptor</i>Gene Promoter 1 Is Associated With Calcium Nephrolithiasis","year":2013,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institutes of Health; Università di Pisa; Università degli Studi di Parma; Università degli Studi di Firenze; Università degli Studi di Padova; Cedars-Sinai Medical Center","keywords":"Calcium-sensing receptor; Allele; Single-nucleotide polymorphism; Promoter; Transfection; Calcium; Biology; Molecular biology; Gene; Luciferase; Kidney stones; Genotype; Gene expression; Endocrinology; Internal medicine; Calcium metabolism; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008366791,0.0002847304,0.001471027,0.0001357853,0.0001088121,0.00001275622,0.0002250716,0.0002192481,0.0002299507],"category_scores_gemma":[0.0006697875,0.0001555343,0.0005777287,0.0002379102,0.0006024087,0.000198405,0.00003330142,0.0009201673,0.00004023228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000032589,"about_ca_system_score_gemma":0.0003903877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002151626,"about_ca_topic_score_gemma":0.000007000451,"domain_scores_codex":[0.99658,0.0008383804,0.001303298,0.0002283996,0.000564859,0.0004850467],"domain_scores_gemma":[0.9966058,0.0007924572,0.001136245,0.0003763325,0.000773581,0.0003155926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.03162993,0.01792527,0.1292541,0.00006119715,0.0272668,0.0007183315,0.003079326,0.00005024614,0.6544631,0.0007900324,0.03563756,0.09912415],"study_design_scores_gemma":[0.01976355,0.001791853,0.9038492,0.00007723167,0.003424719,0.001128943,0.0001134574,0.0001381361,0.06197349,0.0009461757,0.006548403,0.000244785],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987016,0.003156394,0.0009138244,0.007724283,0.0003898867,0.0004177081,0.00002072659,0.00001837888,0.0003427554],"genre_scores_gemma":[0.9945459,0.0007308477,0.001801116,0.00220836,0.0003814488,0.00000484361,0.000006635102,0.00003041365,0.0002904252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7745951,"threshold_uncertainty_score":0.6342503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07004968930233783,"score_gpt":0.3562905107230477,"score_spread":0.2862408214207099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}