{"id":"W1977441177","doi":"10.1210/jc.2013-1834","title":"Decreased Transcriptional Activity of<i>Calcium-sensing receptor</i>Gene Promoter 1 Is Associated With Calcium Nephrolithiasis","year":2013,"lang":"en","type":"article","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institutes of Health; Università di Pisa; Università degli Studi di Parma; Università degli Studi di Firenze; Università degli Studi di Padova; Cedars-Sinai Medical Center","keywords":"Calcium-sensing receptor; Allele; Single-nucleotide polymorphism; Promoter; Transfection; Calcium; Biology; Molecular biology; Gene; Luciferase; Kidney stones; Genotype; Gene expression; Endocrinology; Internal medicine; Calcium metabolism; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002409956,0.0003601129,0.0004228459,0.0005936691,0.0001691852,0.0002507707,0.0002607218,0.0003341027,0.002632052],"category_scores_gemma":[0.0009055462,0.0001763971,0.0004102296,0.0005317884,0.0002836026,0.0000816329,0.0001720066,0.0003357398,0.0002941584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001461333,"about_ca_system_score_gemma":0.0001369969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009575339,"about_ca_topic_score_gemma":0.0007292388,"domain_scores_codex":[0.9997167,0.00004913576,0.00003041926,0.0001079496,0.00006056224,0.00003527094],"domain_scores_gemma":[0.9989435,0.0002939263,0.0005524334,0.00004719538,0.00006057592,0.0001023073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003254711,0.0001417628,0.7032886,0.0002510139,0.0003562796,0.001203659,0.0003385259,0.0003997775,0.2820136,0.0001622451,0.0004212557,0.008168585],"study_design_scores_gemma":[0.0000625077,0.0003131764,0.976439,0.00002038108,0.0002338661,0.003671862,0.00007455544,0.0009845692,0.01753224,0.0001544956,0.0004992446,0.00001405018],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988689,0.0002647111,0.0003910048,0.00004101554,0.000007057899,0.000003561975,0.0002419212,0.00002172495,0.0001601915],"genre_scores_gemma":[0.9990755,0.00007009276,0.0003919421,0.00002315023,0.00001069682,0.000004928429,0.0002282168,0.000008153309,0.0001872723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002632052,"threshold_uncertainty_score":0.008805096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07004968930233783,"score_gpt":0.3562905107230477,"score_spread":0.2862408214207099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}