{"id":"W1977461892","doi":"10.1002/jbmr.282","title":"The Rac1 exchange factor Dock5 is essential for bone resorption by osteoclasts","year":2010,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Ligue Contre le Cancer; Canadian Institutes of Health Research; Association pour la Recherche sur le Cancer","keywords":"Osteoclast; Bone resorption; RAC1; Cell biology; Resorption; Podosome; Osteoporosis; Bone remodeling; Chemistry; In vivo; Actin cytoskeleton; Cancer research; Internal medicine; Biology; Endocrinology; Cytoskeleton; In vitro; Medicine; Signal transduction; Cell; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000895741,0.00008971514,0.0001513111,0.00007631016,0.0002233502,0.0001026754,0.0001077421,0.0001115076,0.00003006849],"category_scores_gemma":[0.0004940511,0.00005741824,0.0001206641,0.00006992959,0.0001609455,0.00001323249,0.00009139011,0.0002603336,0.000002006162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003956377,"about_ca_system_score_gemma":0.0001088187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002730312,"about_ca_topic_score_gemma":0.00008838486,"domain_scores_codex":[0.9988831,0.00008124452,0.0002607533,0.0001475038,0.0003348573,0.0002925244],"domain_scores_gemma":[0.9990052,0.00008229652,0.0001165828,0.0001698662,0.000444563,0.0001814888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006260899,0.00005063205,0.0001973172,0.00001862189,0.000020567,0.000003861919,0.00003920452,5.219504e-8,0.8531012,0.00002729326,0.132125,0.01379022],"study_design_scores_gemma":[0.001495161,0.0005648875,0.003325705,0.00001146181,0.0000218424,0.00006728549,0.00009466295,0.00001436545,0.2985426,0.0002253855,0.6955325,0.0001041026],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874556,0.01021935,0.0001266148,0.001614921,0.0002485159,0.000152519,0.00007941928,0.000001364279,0.0001016859],"genre_scores_gemma":[0.9882739,0.003644048,0.0001969227,0.00009285803,0.001327322,0.00001289576,0.00002089669,0.00001437764,0.006416837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5634075,"threshold_uncertainty_score":0.2341448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02182365020006189,"score_gpt":0.344689889278361,"score_spread":0.3228662390782991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}