{"id":"W1977461892","doi":"10.1002/jbmr.282","title":"The Rac1 exchange factor Dock5 is essential for bone resorption by osteoclasts","year":2010,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Ligue Contre le Cancer; Canadian Institutes of Health Research; Association pour la Recherche sur le Cancer","keywords":"Osteoclast; Bone resorption; RAC1; Cell biology; Resorption; Podosome; Osteoporosis; Bone remodeling; Chemistry; In vivo; Actin cytoskeleton; Cancer research; Internal medicine; Biology; Endocrinology; Cytoskeleton; In vitro; Medicine; Signal transduction; Cell; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014822,0.0002126541,0.0002844943,0.0001978293,0.0002276857,0.0004864837,0.0001972275,0.0002278733,0.0009051019],"category_scores_gemma":[0.0001875911,0.0001614577,0.0001810103,0.00009944836,0.0002673388,0.000172881,0.000238137,0.0003106754,0.0002606117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003655299,"about_ca_system_score_gemma":0.0002582513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007816565,"about_ca_topic_score_gemma":0.0009098666,"domain_scores_codex":[0.9998441,0.00002286391,0.00002012525,0.00002656812,0.00005783094,0.00002847447],"domain_scores_gemma":[0.9998968,0.00001459024,0.00003970413,0.000008116819,0.00001000571,0.00003081113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002243987,0.00001501781,0.000487346,0.00007234943,0.000006830066,0.0001120005,0.000007837223,0.0001584172,0.9964228,0.0003324847,0.00004327076,0.002117199],"study_design_scores_gemma":[0.00006701562,0.0002424476,0.0194307,0.00001912878,0.00004797285,0.001822247,0.00004512993,0.003934936,0.9656768,0.000257234,0.008443684,0.00001264983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853142,0.007129663,0.005649378,0.0001767047,0.00002512681,0.0000153994,0.0002825373,0.00009135759,0.001315517],"genre_scores_gemma":[0.9964456,0.000915095,0.001710251,0.00002437941,0.000005127351,0.000006109803,0.0002186677,0.000008058551,0.0006667259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009051019,"threshold_uncertainty_score":0.003027856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02182365020006189,"score_gpt":0.344689889278361,"score_spread":0.3228662390782991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}