{"id":"W1977488202","doi":"10.1128/jvi.03104-12","title":"The Highly Conserved Layer-3 Component of the HIV-1 gp120 Inner Domain Is Critical for CD4-Required Conformational Transitions","year":2012,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Trimer; Glycoprotein; Conformational change; Protein subunit; Biology; Biophysics; Allosteric regulation; Viral envelope; Domain (mathematical analysis); Protein structure; Human immunodeficiency virus (HIV); Cell biology; Layer (electronics); Envelope (radar); Biochemistry; Chemistry; Virology; Materials science; Nanotechnology; Enzyme; Dimer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009352571,0.0002255941,0.0001155274,0.00005554515,0.0001589737,0.0002242177,0.0001903839,0.0002204178,0.0009600067],"category_scores_gemma":[0.0001571356,0.00008118744,0.000147479,0.00005596374,0.0002228613,0.0001884218,0.0002174569,0.0003969292,0.0004011786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000222438,"about_ca_system_score_gemma":0.0001908739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002984056,"about_ca_topic_score_gemma":0.0003016479,"domain_scores_codex":[0.9999449,0.00001197262,0.000003062061,0.000008613615,0.00001595106,0.00001546126],"domain_scores_gemma":[0.9999334,0.00001044899,0.00002249741,0.000006729345,0.000006562623,0.00002031181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000198793,0.00002437493,0.0005641393,0.0000372969,0.000003814415,0.00008932703,0.00001590474,0.00007132062,0.9956906,0.000203966,0.00007765427,0.003022785],"study_design_scores_gemma":[0.00004189998,0.0003136845,0.02888771,0.00002540163,0.00002500399,0.001210412,0.00008162973,0.00157263,0.957647,0.0004942194,0.009689042,0.00001143486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992031,0.002469698,0.003562198,0.0001195703,0.00003601749,0.00002918577,0.0001439058,0.00005907715,0.001549335],"genre_scores_gemma":[0.9952369,0.0006385525,0.002294386,0.00006752848,0.000009516428,0.0000136541,0.0002372964,0.00002141384,0.001480804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009600067,"threshold_uncertainty_score":0.003211498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02838026993759319,"score_gpt":0.2988695463364533,"score_spread":0.2704892763988601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}