{"id":"W1977527571","doi":"10.1371/journal.ppat.1000751","title":"Structural and Biochemical Characterization of SrcA, a Multi-Cargo Type III Secretion Chaperone in Salmonella Required for Pathogenic Association with a Host","year":2010,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Salmonella and Campylobacter epidemiology","field":"Agricultural and Biological Sciences","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of British Columbia; University of Toronto; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Effector; Type three secretion system; Chaperone (clinical); Salmonella enterica; Biology; Secretion; Cell biology; Intracellular parasite; Salmonella; Transport protein; Microbiology; Virulence; Intracellular; Bacteria; Genetics; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001471021,0.0002634231,0.0002011048,0.0001498913,0.0001667307,0.0002077775,0.0002205309,0.0002572011,0.0003388207],"category_scores_gemma":[0.0001885152,0.0001272063,0.0003413702,0.0002094078,0.0002042207,0.0001150235,0.0001387221,0.0003914211,0.0002651673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005124386,"about_ca_system_score_gemma":0.0003317758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003263375,"about_ca_topic_score_gemma":0.003689598,"domain_scores_codex":[0.9999299,0.000009569978,0.000006537639,0.00001594503,0.00002591626,0.00001220875],"domain_scores_gemma":[0.9998018,0.00001703193,0.00004875373,0.00001268823,0.00004089087,0.00007890774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001629724,0.00004370077,0.001109734,0.00004725968,0.00001100582,0.0002386251,0.00003633488,0.000394899,0.9967468,0.0001064642,0.0001358051,0.0009664038],"study_design_scores_gemma":[0.00009679689,0.0008913291,0.1094709,0.00003540634,0.0001004768,0.002558414,0.0003764651,0.0164535,0.8560467,0.0002421477,0.01368134,0.00004641076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977236,0.0005093631,0.0007475708,0.00009716859,0.00001671927,0.000007886258,0.000524161,0.00002292972,0.0003505562],"genre_scores_gemma":[0.9939421,0.0003607774,0.001716994,0.00004688114,0.000009510159,0.000008888746,0.002909543,0.00002135313,0.000983903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003263375,"threshold_uncertainty_score":0.0064888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02465510734624912,"score_gpt":0.2280161313488708,"score_spread":0.2033610240026217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}