{"id":"W1977529605","doi":"10.1007/s10637-014-0066-9","title":"Phase II trial of vorinostat in advanced melanoma","year":2014,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"Juravinski Cancer Centre; Princess Margaret Cancer Centre","funders":"National Cancer Institute; Cancer Research UK","keywords":"Vorinostat; Clinical endpoint; Medicine; Melanoma; Adverse effect; Nausea; Internal medicine; Oncology; Progressive disease; Response Evaluation Criteria in Solid Tumors; Phases of clinical research; Chemotherapy; Randomized controlled trial; Cancer research; Histone deacetylase; Histone; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009829482,0.001479951,0.002021085,0.0005664434,0.0005356312,0.001002773,0.0006998265,0.001152768,0.005049392],"category_scores_gemma":[0.0005601037,0.0004722961,0.00120558,0.0004020216,0.0009770828,0.0008160818,0.0003144293,0.002833804,0.0009922151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009938901,"about_ca_system_score_gemma":0.001196299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001997523,"about_ca_topic_score_gemma":0.00441551,"domain_scores_codex":[0.9997626,0.00009785001,0.000007948768,0.00003482451,0.00001796728,0.00007879711],"domain_scores_gemma":[0.9995667,0.00007333238,0.00004428711,0.00003409323,0.00001755314,0.0002639398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7203366,0.04620254,0.004454214,0.001211002,0.001155669,0.0006971311,0.0004192819,0.005264089,0.06652183,0.0009562297,0.01034594,0.1424356],"study_design_scores_gemma":[0.5724859,0.4045887,0.008427967,0.00006373781,0.000331461,0.0003601363,0.0001432265,0.002077088,0.005774871,0.0005516208,0.005159352,0.00003581985],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848664,0.004388374,0.0006212661,0.001509287,0.0005606568,0.001875806,0.001690155,0.0001419261,0.004346087],"genre_scores_gemma":[0.9801362,0.00385748,0.001092513,0.001186659,0.0003241648,0.001769147,0.003402849,0.00004898575,0.008182024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005049392,"threshold_uncertainty_score":0.01689184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01300294792304773,"score_gpt":0.2994760520324806,"score_spread":0.2864731041094329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}