{"id":"W1977539403","doi":"10.1021/bi051132d","title":"A Novel Carbonic Anhydrase II Binding Site Regulates NHE1 Activity","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Carbonic anhydrase II; Amino acid; Carbonic anhydrase; Biochemistry; Chemistry; Binding site; Gene isoform; Phosphorylation; Molecular biology; Biology; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008636653,0.0002277808,0.0002646281,0.00008713338,0.000200927,0.0001913612,0.00019728,0.0002447092,0.001344865],"category_scores_gemma":[0.0001088187,0.000131201,0.0001566585,0.00007746885,0.0001756967,0.0001724665,0.0001595236,0.0003900162,0.0006996362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003462909,"about_ca_system_score_gemma":0.0002192273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003712186,"about_ca_topic_score_gemma":0.0007824927,"domain_scores_codex":[0.9999304,0.000007370783,0.00000331002,0.00002375654,0.00001929337,0.00001582801],"domain_scores_gemma":[0.9998845,0.00001843823,0.00003113935,0.000009107311,0.00001793855,0.00003891472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003206285,0.000007633875,0.0001277732,0.000009036499,9.154583e-7,0.00002877073,0.000003833753,0.0000291292,0.9991822,0.00007194457,0.00001447315,0.0004922844],"study_design_scores_gemma":[0.00002540779,0.0001571826,0.02088931,0.000006699934,0.0000104551,0.0004284925,0.00001704273,0.002016794,0.9742517,0.0001453772,0.002042657,0.000008880001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927598,0.0008865487,0.004856096,0.00007557878,0.00001614139,0.00001909916,0.0001310633,0.00007331503,0.001182342],"genre_scores_gemma":[0.9909407,0.0004868603,0.005673889,0.00008916104,0.00001373065,0.00001779365,0.0004316216,0.00003125192,0.002315079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001344865,"threshold_uncertainty_score":0.004499018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0055867500843945,"score_gpt":0.2038844719347439,"score_spread":0.1982977218503494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}