{"id":"W1977545536","doi":"10.1002/stem.1389","title":"Disease-Causing Mitochondrial Heteroplasmy Segregated Within Induced Pluripotent Stem Cell Clones Derived from a Patient with MELAS","year":2013,"lang":"en","type":"article","venue":"Stem Cells","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Heteroplasmy; Biology; Induced pluripotent stem cell; Stem cell; Disease; MELAS syndrome; Mitochondrial DNA; Mitochondrion; Genetics; Cell; Mitochondrial disease; Reprogramming; Cell biology; Mitochondrial myopathy; Gene; Embryonic stem cell; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001219538,0.0002709598,0.0002392571,0.0003385846,0.0001703278,0.0002204403,0.00009888278,0.0003132731,0.0009819532],"category_scores_gemma":[0.0002785077,0.00008850693,0.0002068877,0.0001956202,0.0001862599,0.00009867857,0.0002017186,0.0003686427,0.0002792751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001137896,"about_ca_system_score_gemma":0.00007601087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001855158,"about_ca_topic_score_gemma":0.0002571231,"domain_scores_codex":[0.9998895,0.000009778634,0.00002417568,0.00003255714,0.00003333128,0.00001056228],"domain_scores_gemma":[0.9998987,0.0000319153,0.00002004781,0.00001631211,0.00001186365,0.0000211697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001048827,0.00003447449,0.006482376,0.00003131884,0.0000150914,0.007961718,0.0001591553,0.0001607106,0.9797474,0.000204552,0.00005292482,0.005045368],"study_design_scores_gemma":[0.00004624766,0.0009899593,0.07643003,0.00003513763,0.0001341169,0.103516,0.0002602971,0.003795479,0.8090628,0.0004046371,0.005302222,0.0000229907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963101,0.0001591915,0.002618074,0.00005385689,0.000009148858,0.00003714054,0.0002031468,0.00004392738,0.0005654515],"genre_scores_gemma":[0.9973093,0.0001771534,0.001507141,0.00003820181,0.000005431988,0.00001856975,0.0004172306,0.00001425109,0.000512823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009819532,"threshold_uncertainty_score":0.003284991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01166126534573222,"score_gpt":0.1920614613732657,"score_spread":0.1804001960275335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}