{"id":"W1977546494","doi":"10.1139/o09-155","title":"Structure and dynamics changes induced by 2,2,2-trifluoro-ethanol (TFE) on the N-terminal half of hepatitis C virus core proteinThis paper is one of a selection of papers published in this special issue entitled “Canadian Society of Biochemistry, Molecular & Cellular Biology 52nd Annual Meeting — Protein Folding: Principles and Diseases” and has undergone the Journal's usual peer review process.","year":2010,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Circular dichroism; Chemistry; Protein secondary structure; Core protein; Biophysics; Nucleic acid; Protein structure; RNA; Crystallography; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009655389,0.0001732679,0.0001150634,0.00009098562,0.0001477154,0.0001403348,0.0001760668,0.000198052,0.001082992],"category_scores_gemma":[0.0002108859,0.0001078669,0.0001352118,0.00009211108,0.0001966979,0.0001969145,0.00007105828,0.0002916855,0.00020429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000282685,"about_ca_system_score_gemma":0.0001027727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001250162,"about_ca_topic_score_gemma":0.001190954,"domain_scores_codex":[0.9999464,0.000008566065,0.000001840832,0.00001146673,0.00001167475,0.00002017293],"domain_scores_gemma":[0.9998946,0.00002921428,0.00003273752,0.000005117801,0.00001685093,0.00002143934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004007658,0.00004444571,0.0004842436,0.00003512353,0.00001300002,0.0001410885,0.00009075005,0.0002485379,0.9970064,0.0001225279,0.0001490583,0.001264119],"study_design_scores_gemma":[0.00004574555,0.0004191721,0.01672074,0.00001189857,0.000021215,0.0002457366,0.00008843185,0.005954876,0.9746783,0.00006802585,0.001727067,0.00001868359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982547,0.000345455,0.000437765,0.00005391407,0.00001447594,0.000005764012,0.00009483227,0.00001570197,0.0007772613],"genre_scores_gemma":[0.9977595,0.000285767,0.0005400627,0.00006144027,0.000007793648,0.0000130526,0.0002699399,0.00001206347,0.001050373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001250162,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01957330250366784,"score_gpt":0.2724325663093602,"score_spread":0.2528592638056924,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}