{"id":"W1977560681","doi":"10.1016/j.bcp.2005.04.037","title":"Mechanism of action of a novel “combi-triazene” engineered to possess a polar functional group on the alkylating moiety: Evidence for enhancement of potency","year":2005,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Royal Victoria Regional Health Centre; Health Canada; Royal Victoria Hospital","funders":"National Cancer Institute","keywords":"Chemistry; Mechanism of action; Tyrosine kinase; In vivo; Moiety; In vitro; Epidermal growth factor; Triazene; Potency; Biochemistry; Epidermal growth factor receptor; Tyrosine phosphorylation; Kinase; Pharmacology; Biology; Stereochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001726627,0.0001332599,0.0002145177,0.00002781881,0.00004542301,0.000002387186,0.000229978,0.0001303059,0.0004883372],"category_scores_gemma":[0.0001991627,0.0001179009,0.0001295826,0.0001452534,0.00005887697,0.000032108,0.00006708154,0.0001419035,0.000001809615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000077419,"about_ca_system_score_gemma":0.00004440907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001188077,"about_ca_topic_score_gemma":2.639651e-7,"domain_scores_codex":[0.9989464,0.000007900217,0.0004399968,0.0002517647,0.0001770432,0.0001768765],"domain_scores_gemma":[0.9986698,0.0006682936,0.0002516308,0.0001989927,0.000146893,0.00006437318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003710122,0.0006468876,0.000002773183,0.0002034957,0.00007760078,4.418173e-8,0.00004443168,0.00009177123,0.9933712,0.001741017,0.002860676,0.0005891149],"study_design_scores_gemma":[0.0008745183,0.00007109628,0.000009342804,0.00008149004,0.00008249849,0.000002220323,0.0000526294,0.00126076,0.9967166,0.0001876244,0.0005622084,0.00009904989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804317,0.0001296008,0.01706462,0.001721531,0.0000690789,0.0002775098,0.0001066976,0.00001704016,0.0001822733],"genre_scores_gemma":[0.9966807,0.00002331199,0.002372202,0.0002026271,0.0002823962,0.0002504454,0.00003857123,0.00001223249,0.0001375545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01624901,"threshold_uncertainty_score":0.534695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09915745979993519,"score_gpt":0.3611441676595064,"score_spread":0.2619867078595712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}