{"id":"W1977589606","doi":"10.1002/cpt.10","title":"Soluble Guanylate Cyclase: A New Therapeutic Target for Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension","year":2014,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Riociguat; Nitric oxide; Cyclic guanosine monophosphate; Pulmonary hypertension; Medicine; Heme; Pharmacology; Soluble guanylyl cyclase; Vasodilation; cGMP-dependent protein kinase; Internal medicine; Cardiology; Chronic thromboembolic pulmonary hypertension; Chemistry; Guanylate cyclase; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003435821,0.0006191658,0.001078032,0.001732903,0.0002714179,0.0007299877,0.0005772133,0.0009980971,0.004617302],"category_scores_gemma":[0.0003087007,0.0002006126,0.0005322722,0.001568755,0.0003683829,0.001137643,0.0005326604,0.0021072,0.001870561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004344748,"about_ca_system_score_gemma":0.0008269164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007844476,"about_ca_topic_score_gemma":0.002090484,"domain_scores_codex":[0.9998844,0.00001844752,0.00001599079,0.00002042199,0.00004642547,0.00001439421],"domain_scores_gemma":[0.9998674,0.00005123506,0.00002169691,0.000004385124,0.00003974422,0.00001552539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000865668,0.0001021308,0.0001739651,0.01510839,0.00009230354,0.0002793065,0.00007852331,0.0002401952,0.00343059,0.004218969,0.0299351,0.946254],"study_design_scores_gemma":[0.00003299705,0.0001077358,0.0007938159,0.002503972,0.0001247266,0.001414381,0.00006198819,0.0001030725,0.0005133045,0.001957833,0.9923708,0.00001538127],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001574971,0.9982823,0.0001096311,0.0003750002,0.0001805054,0.000004903885,0.00001717765,0.000006834594,0.0008660819],"genre_scores_gemma":[0.001063735,0.997357,0.0002300505,0.0002953293,0.0001488912,0.000007419898,0.00004402784,0.000001538872,0.0008520783],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004617302,"threshold_uncertainty_score":0.01544642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1788209408837836,"score_gpt":0.4487858328702332,"score_spread":0.2699648919864495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}