{"id":"W1977608358","doi":"10.1016/j.neuropharm.2012.05.029","title":"Orthosteric and allosteric drug binding sites in the Caenorhabditis elegans mgl-2 metabotropic glutamate receptor","year":2012,"lang":"en","type":"article","venue":"Neuropharmacology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Metabotropic glutamate receptor; Metabotropic glutamate receptor 5; Allosteric regulation; Metabotropic glutamate receptor 3; Metabotropic glutamate receptor 4; Metabotropic glutamate receptor 7; Metabotropic glutamate receptor 2; Metabotropic glutamate receptor 1; Pharmacology; Caenorhabditis elegans; Metabotropic receptor; Metabotropic glutamate receptor 6; Chemistry; Glutamate receptor; Neuroscience; Biology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003075627,0.0003282339,0.0006302609,0.0003128111,0.0006262267,0.0004923454,0.0007581952,0.0007073274,0.002396804],"category_scores_gemma":[0.0003159709,0.0004389665,0.0005139369,0.0001424283,0.0006800817,0.0003808964,0.0004110905,0.0006357921,0.0007080919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009660035,"about_ca_system_score_gemma":0.0006145976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00524848,"about_ca_topic_score_gemma":0.0184303,"domain_scores_codex":[0.9996445,0.00004573372,0.0000279329,0.00005431055,0.0001385605,0.00008892751],"domain_scores_gemma":[0.9998777,0.00002048441,0.00003111741,0.00001467157,0.00001604133,0.00003989999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001084057,0.0001240092,0.0004842833,0.00009897744,0.00002284421,0.0002855166,0.00004510266,0.000839561,0.9910384,0.00186549,0.0003226431,0.003789149],"study_design_scores_gemma":[0.0005798101,0.001140773,0.01407528,0.00006928107,0.0001253463,0.001527896,0.0001531576,0.02271642,0.9534648,0.0008209571,0.005203477,0.0001228216],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911457,0.0007846792,0.004097074,0.0002835081,0.00004935613,0.00003626211,0.0002338916,0.0001328616,0.003236651],"genre_scores_gemma":[0.9947324,0.0002874194,0.002969563,0.0001851133,0.000009050874,0.00002173738,0.0001465539,0.00001759642,0.00163065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00524848,"threshold_uncertainty_score":0.01043588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05972190719441066,"score_gpt":0.3423206946259892,"score_spread":0.2825987874315785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}