{"id":"W1977609704","doi":"10.1097/cad.0b013e32832f4aa8","title":"Methotrexate-induced apoptosis is enhanced by altered expression of methylenetetrahydrofolate reductase","year":2009,"lang":"en","type":"article","venue":"Anti-Cancer Drugs","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital","funders":"","keywords":"Methylenetetrahydrofolate reductase; TUNEL assay; Apoptosis; Methotrexate; Terminal deoxynucleotidyl transferase; Hyperhomocysteinemia; Methyltransferase; Pharmacology; Chemistry; Homocysteine; Molecular biology; Biology; Endocrinology; Internal medicine; Cancer research; Methylation; Biochemistry; Medicine; DNA; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001310337,0.0002238454,0.0002385092,0.0003389361,0.00009243373,0.0002034753,0.0001015738,0.0002721575,0.00103477],"category_scores_gemma":[0.0001572643,0.0001334016,0.000261426,0.0001691169,0.0001174903,0.0001394296,0.0001483741,0.0003868155,0.0002959419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002347758,"about_ca_system_score_gemma":0.00008694886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003438832,"about_ca_topic_score_gemma":0.0004041693,"domain_scores_codex":[0.9997686,0.00004180377,0.0000288826,0.00004821446,0.00007040866,0.00004211067],"domain_scores_gemma":[0.999808,0.00001971643,0.00009333251,0.00002085284,0.00002581195,0.00003224759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001465862,0.00001333811,0.0009928803,0.00002245945,0.000006337083,0.00007765916,0.00001258948,0.0000123198,0.9977304,0.00003416574,0.00001404483,0.0009372652],"study_design_scores_gemma":[0.00002874575,0.0005974921,0.05069324,0.00001377431,0.00003963906,0.001197881,0.00002921238,0.0005238089,0.9448724,0.0000581202,0.001940476,0.000005175787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931303,0.003585979,0.001780865,0.0000552798,0.00001891352,0.00001601738,0.0002946526,0.00007125122,0.001046675],"genre_scores_gemma":[0.9962347,0.001180416,0.0008547686,0.00003195577,0.000008006568,0.00001980528,0.0003168606,0.000007028037,0.001346607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00103477,"threshold_uncertainty_score":0.003461659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02680360271157377,"score_gpt":0.35476926397037,"score_spread":0.3279656612587962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}