{"id":"W1977641480","doi":"10.1073/pnas.0704998104","title":"Molecular imaging of membrane interfaces reveals mode of β-glucosidase activation by saposin C","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Förster resonance energy transfer; Chemistry; Bilayer; Membrane; Lipid bilayer; Biophysics; Enzyme; Confocal microscopy; Biochemistry; Cell biology; Fluorescence; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006247185,0.00008042104,0.0001333985,0.00008571855,0.0000405408,0.000004901883,0.0004258095,0.00007133772,0.000003624217],"category_scores_gemma":[0.0002084018,0.0000570751,0.00006514055,0.000271789,0.0004744433,0.00002900881,0.00008907761,0.0000659411,4.773624e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007772332,"about_ca_system_score_gemma":0.00002088184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009674481,"about_ca_topic_score_gemma":5.655837e-8,"domain_scores_codex":[0.9988483,0.000005036345,0.0003403236,0.0001759686,0.0005221728,0.0001081706],"domain_scores_gemma":[0.9991643,0.00002199576,0.0004928642,0.00001261226,0.0002864226,0.00002180624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003826279,0.00003211194,0.002820892,0.00007131154,0.00001103953,1.950131e-9,0.0000505336,0.00003464922,0.9956144,0.0008133113,0.0001743272,0.0003391747],"study_design_scores_gemma":[0.0001522542,0.00004522232,0.004336997,0.00006907231,0.00001435596,0.000002721883,0.00009440062,0.00003415711,0.9943655,0.0007795262,0.00004851221,0.00005732558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982591,0.00009431013,0.00001981,0.0004324234,0.00001303344,0.000113406,0.00002224686,0.000001921979,0.001043758],"genre_scores_gemma":[0.9990985,0.00001677271,0.0006965071,0.0001129626,0.00003121611,0.000001739739,0.000001201515,0.000003894067,0.00003715035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001516106,"threshold_uncertainty_score":0.2327455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01355302555109169,"score_gpt":0.3041052449188639,"score_spread":0.2905522193677722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}