{"id":"W1977700149","doi":"10.1021/tx900087z","title":"Covalent Binding of Penicillamine to Macrophages: Implications for Penicillamine-Induced Autoimmunity","year":2009,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Penicillamine; Chemistry; Macrophage; Aldehyde; Autoimmunity; Hydrazide; Biochemistry; Immunology; Antibody; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003253502,0.000448626,0.0002042955,0.0001773123,0.0001658345,0.0002213262,0.0002338647,0.0005574605,0.0009817769],"category_scores_gemma":[0.0001405273,0.0001197622,0.0002427262,0.00008335467,0.0004004417,0.0003118915,0.000212649,0.0003531525,0.0001919217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001893872,"about_ca_system_score_gemma":0.0001010558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002142129,"about_ca_topic_score_gemma":0.0002819064,"domain_scores_codex":[0.9998792,0.00004573914,0.00001104683,0.00001902738,0.00001626358,0.00002867366],"domain_scores_gemma":[0.9998782,0.00003044109,0.0000420631,0.00001257701,0.0000150061,0.00002164616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003666205,0.00008651572,0.003524038,0.0002621389,0.00001702154,0.001298321,0.00006235994,0.0001428558,0.9890014,0.0005019694,0.00006019748,0.004676516],"study_design_scores_gemma":[0.00008718319,0.002436759,0.06075132,0.00008002965,0.0001033245,0.007253091,0.0003202385,0.002226765,0.9196323,0.00110331,0.005981802,0.00002389063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9679525,0.02282553,0.00510053,0.0008203616,0.00008597004,0.00004633942,0.00007431392,0.00004295697,0.003051412],"genre_scores_gemma":[0.9921483,0.005650457,0.0009833298,0.0002125262,0.00004983318,0.00001438734,0.00003348655,0.000002433833,0.0009053124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009817769,"threshold_uncertainty_score":0.003284395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1219707869325212,"score_gpt":0.4102207706032669,"score_spread":0.2882499836707457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}