{"id":"W1977729493","doi":"10.1371/journal.pone.0087255","title":"Increased Axonal Ribosome Numbers Is an Early Event in the Pathogenesis of Amyotrophic Lateral Sclerosis","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"Centre for Medical Systems Biology; European Commission; Multiple Sclerosis Society; Natural Sciences and Engineering Research Council of Canada; Multiple Sclerosis Society of Canada","keywords":"Amyotrophic lateral sclerosis; SOD1; Axon; Biology; Neurodegeneration; Neuroscience; Motor neuron; Axoplasmic transport; Axotomy; Population; Cell biology; Pathology; Medicine; Central nervous system; Spinal cord; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000172976,0.0004259,0.000311152,0.0007560963,0.0002382803,0.0002609447,0.0001430962,0.0004609736,0.000740512],"category_scores_gemma":[0.0001324427,0.0002251056,0.0002008471,0.0003260144,0.0002985246,0.0002339488,0.0002998101,0.0003245621,0.0003169094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001854212,"about_ca_system_score_gemma":0.00009611157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003288478,"about_ca_topic_score_gemma":0.0003620751,"domain_scores_codex":[0.9998202,0.00002314311,0.00002276335,0.00004728475,0.00006326277,0.00002336964],"domain_scores_gemma":[0.9998061,0.00001938757,0.00009775139,0.00001368252,0.00001751156,0.00004557026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001569607,0.00001461859,0.002500584,0.00004985525,0.00001115672,0.0003329544,0.00004108195,0.00002304207,0.9957278,0.00005130912,0.00003298608,0.001057839],"study_design_scores_gemma":[0.00004388464,0.0009472146,0.579814,0.0000522013,0.0001178846,0.006331821,0.0002792569,0.0009408576,0.4052124,0.0006256859,0.005599794,0.00003515273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952639,0.00245639,0.001287252,0.00004913568,0.00001924474,0.00001422438,0.0001884711,0.00009075151,0.0006306054],"genre_scores_gemma":[0.9958453,0.001584119,0.001139319,0.00003688993,0.00003234022,0.00002455008,0.0002803719,0.00001376493,0.001043491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007560963,"threshold_uncertainty_score":0.002477229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08170491022256296,"score_gpt":0.270397336118986,"score_spread":0.1886924258964231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}