{"id":"W1977750952","doi":"10.1385/ct:3:2:89","title":"Dexrazoxane (ICRF-187) Protects Cardiac Myocytes Against Doxorubicin by Preventing Damage to Mitochondria","year":2003,"lang":"en","type":"article","venue":"Cardiovascular Toxicology","topic":"Analytical Chemistry and Sensors","field":"Chemical Engineering","cited_by":89,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Dexrazoxane; Doxorubicin; Propidium iodide; Mitochondrion; Myocyte; Cardiotoxicity; Chemistry; Oxidative stress; Pharmacology; Calcein; Dichlorofluorescein; Reactive oxygen species; Intracellular; Biochemistry; Apoptosis; Biophysics; Anthracycline; Cell biology; Programmed cell death; Biology; Medicine; Internal medicine; Membrane; Toxicity; Cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002170074,0.0005021529,0.000657091,0.0002228449,0.0002387497,0.000286342,0.0003345371,0.0005147004,0.002172307],"category_scores_gemma":[0.0002339165,0.0002556269,0.0002585523,0.0001738761,0.0004081715,0.0003666042,0.0002050241,0.0009553177,0.0005888357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002863467,"about_ca_system_score_gemma":0.0003426325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007689452,"about_ca_topic_score_gemma":0.002076749,"domain_scores_codex":[0.9998344,0.00003345399,0.00002164614,0.00003281062,0.00002552761,0.00005203694],"domain_scores_gemma":[0.9998356,0.00003032621,0.00005830904,0.0000331716,0.000009878943,0.00003265785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002245649,0.0001160694,0.0005971834,0.0001168378,0.00003591424,0.0001135919,0.00004544018,0.0001515125,0.9889741,0.000169779,0.0003207391,0.00711319],"study_design_scores_gemma":[0.0004605998,0.003430212,0.00615452,0.00001619073,0.00005450756,0.0005022708,0.00006479475,0.0003934134,0.985482,0.00005397631,0.003372214,0.00001526231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915612,0.003680298,0.001726654,0.0004247619,0.00009894979,0.00005641496,0.0005708892,0.000228819,0.001652015],"genre_scores_gemma":[0.9944752,0.00152086,0.001256241,0.00008354034,0.00003812974,0.0000339382,0.0007449676,0.00001644572,0.001830634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002172307,"threshold_uncertainty_score":0.007267118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00941829283233433,"score_gpt":0.2151751718947102,"score_spread":0.2057568790623759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}