{"id":"W1977750952","doi":"10.1385/ct:3:2:89","title":"Dexrazoxane (ICRF-187) Protects Cardiac Myocytes Against Doxorubicin by Preventing Damage to Mitochondria","year":2003,"lang":"en","type":"article","venue":"Cardiovascular Toxicology","topic":"Analytical Chemistry and Sensors","field":"Chemical Engineering","cited_by":89,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Dexrazoxane; Doxorubicin; Propidium iodide; Mitochondrion; Myocyte; Cardiotoxicity; Chemistry; Oxidative stress; Pharmacology; Calcein; Dichlorofluorescein; Reactive oxygen species; Intracellular; Biochemistry; Apoptosis; Biophysics; Anthracycline; Cell biology; Programmed cell death; Biology; Medicine; Internal medicine; Membrane; Toxicity; Cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005832646,0.0004188849,0.0009660225,0.0000774132,0.0001438662,0.00003980225,0.0003448342,0.0004588211,0.0001409958],"category_scores_gemma":[0.00176218,0.000431669,0.001137333,0.0004521749,0.00009511755,0.00008247725,0.0001172353,0.0005483748,0.0002124031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001967381,"about_ca_system_score_gemma":0.00004968392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008139689,"about_ca_topic_score_gemma":9.304263e-7,"domain_scores_codex":[0.9971659,0.0002611172,0.0004589584,0.0008098774,0.000400088,0.0009040962],"domain_scores_gemma":[0.9982387,0.0001925519,0.0000593218,0.000960833,0.00009850466,0.0004500893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000173637,0.00006490144,0.00008815954,0.0001182307,0.001232026,0.00009061556,0.00008360888,0.006029062,0.988529,0.0004281029,0.002481584,0.0008373289],"study_design_scores_gemma":[0.0005788386,0.00004568551,0.00003328109,0.00004231347,0.0002358364,0.00001947452,0.00009703849,0.0005269453,0.8403723,0.00004893127,0.1574831,0.0005162865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9554543,0.00395377,0.01490559,0.0001700742,0.0005988556,0.001066888,0.00003479228,0.0003669799,0.02344871],"genre_scores_gemma":[0.9930103,0.00007573348,0.002775379,0.0003152928,0.0003395302,0.0001844795,0.0000441729,0.00009409654,0.003160947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1550015,"threshold_uncertainty_score":0.9998135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00941829283233433,"score_gpt":0.2151751718947102,"score_spread":0.2057568790623759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}