{"id":"W1977789763","doi":"10.1038/ng957","title":"Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy","year":2002,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":476,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Western University; Xenon Pharmaceuticals (Canada); Izaak Walton Killam Health Centre; Dalhousie University","funders":"","keywords":"Frizzled; Biology; Wnt signaling pathway; Genetics; Positional cloning; Mutant; Wild type; Cell biology; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000169942,0.0002704114,0.0002013859,0.00009042113,0.00007506727,0.00002655729,0.0003332494,0.000561648,0.000164943],"category_scores_gemma":[0.0000770061,0.0002606614,0.0001107429,0.0002725625,0.0001067918,0.000003343775,0.0001388763,0.0003080488,0.00003482566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004061119,"about_ca_system_score_gemma":0.00004688138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000041655,"about_ca_topic_score_gemma":0.00003144945,"domain_scores_codex":[0.9983807,0.00007389361,0.0002960445,0.00054823,0.0002863931,0.0004147413],"domain_scores_gemma":[0.9993339,0.00001455523,0.0000926744,0.0003454337,0.0001161299,0.00009736448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002599103,0.0002172083,0.09829016,0.00003618347,0.0001092915,0.00009570352,0.0007798963,0.0001179236,0.8715852,0.00005163734,0.01051807,0.01793879],"study_design_scores_gemma":[0.001793624,0.0004417666,0.03158477,0.00005204435,0.0000473755,0.00004040701,0.0001813105,0.0003142123,0.9095973,0.0001943118,0.0549694,0.0007835088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837207,0.01262867,0.0001342919,0.0001670237,0.0005188176,0.0002036899,0.00003983724,0.00001953616,0.002567453],"genre_scores_gemma":[0.9941429,0.001698752,0.00204643,0.0004846012,0.0005791582,0.00003390041,0.0001126902,0.00004187962,0.0008596547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06670539,"threshold_uncertainty_score":0.9999846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00828874880210074,"score_gpt":0.2383897579934564,"score_spread":0.2301010091913556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}