{"id":"W1977830912","doi":"10.1067/mcp.2001.116977","title":"Simple approach to predict the maximal effect elicited by a drug when plasma concentrations are not available or are dissociated from the effect, as illustrated with chondroitin sulfate data","year":2001,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Analytical Methods in Pharmaceuticals","field":"Chemistry","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chondroitin sulfate; Simple (philosophy); Drug; Plasma concentration; Pharmacology; Chemistry; Medicine; Biochemistry; Glycosaminoglycan; Philosophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002339792,0.002494973,0.002963068,0.00206046,0.0003201926,0.001208425,0.001857476,0.001619531,0.003607127],"category_scores_gemma":[0.003129403,0.0007144197,0.00124681,0.001082622,0.0007314549,0.001491096,0.0005147323,0.002493856,0.007322085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007972342,"about_ca_system_score_gemma":0.00111599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001302277,"about_ca_topic_score_gemma":0.002453915,"domain_scores_codex":[0.9990563,0.0001763751,0.0001136642,0.0001954971,0.0004249855,0.00003330639],"domain_scores_gemma":[0.9988236,0.0005501147,0.0001611516,0.00008439604,0.0003514943,0.0000292897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0004005478,0.0002867522,0.002446956,0.01032758,0.0005239351,0.0002698161,0.0001097965,0.01178847,0.195596,0.01276855,0.01589081,0.7495908],"study_design_scores_gemma":[0.0002585189,0.004118362,0.01543899,0.001728121,0.001634592,0.005359222,0.0002862864,0.07244446,0.4565242,0.04574996,0.3958925,0.0005648818],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.01516383,0.23656,0.711612,0.001947107,0.001728641,0.0008680939,0.003270057,0.002515862,0.02633444],"genre_scores_gemma":[0.1427496,0.2846869,0.5366862,0.002102646,0.0009263073,0.002154344,0.003699238,0.0002666464,0.02672813],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003607127,"threshold_uncertainty_score":0.01237416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2298775033815515,"score_gpt":0.4733341753467988,"score_spread":0.2434566719652473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}