{"id":"W1977858281","doi":"10.1021/bi401285j","title":"Characterization of the Role of a Highly Conserved Sequence in ATP Binding Cassette Transporter G (ABCG) Family in ABCG1 Stability, Oligomerization, and Trafficking","year":2013,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"ABCG1; ATP-binding cassette transporter; Mutant; Efflux; Biochemistry; Transporter; Biology; ABCA1; Wild type; Cyclic nucleotide-binding domain; Membrane transport protein; Cell biology; Chemistry; Peptide sequence; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001190692,0.00009998853,0.0002436552,0.00005108095,0.00001247945,0.000006796762,0.00006974373,0.00009633713,0.00001528962],"category_scores_gemma":[0.00003270465,0.0000799419,0.00003644876,0.0002512798,0.0001089138,0.00007132217,0.00001741285,0.0001045306,3.880189e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000250182,"about_ca_system_score_gemma":0.00007549901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002233305,"about_ca_topic_score_gemma":0.00001310755,"domain_scores_codex":[0.9991567,0.00002301119,0.0003851743,0.0001784379,0.0001330494,0.0001236422],"domain_scores_gemma":[0.9995449,0.00001839459,0.0001368699,0.0001976188,0.00006135063,0.0000408213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001663725,0.00004941466,0.2726108,0.0001802957,0.000004529642,6.25065e-7,0.0008027123,5.267351e-7,0.7257451,0.000002885715,4.249443e-7,0.0005860953],"study_design_scores_gemma":[0.0004610119,0.0000058684,0.4556936,0.0001767683,0.00001020936,0.000003474831,0.0002051871,0.0001085975,0.5432609,0.00000361035,0.00003047503,0.00004033278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991367,0.0001348449,0.00000447714,0.0003060535,0.00003329288,0.000275759,0.00003256945,0.000008763429,0.00006749695],"genre_scores_gemma":[0.9997042,0.00004245931,0.00003495392,0.00008910509,0.00002872605,0.00001713271,0.00005136788,0.000009624586,0.00002236183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1830828,"threshold_uncertainty_score":0.3259936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01501457724646483,"score_gpt":0.2231677565043718,"score_spread":0.208153179257907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}