{"id":"W1977858281","doi":"10.1021/bi401285j","title":"Characterization of the Role of a Highly Conserved Sequence in ATP Binding Cassette Transporter G (ABCG) Family in ABCG1 Stability, Oligomerization, and Trafficking","year":2013,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"ABCG1; ATP-binding cassette transporter; Mutant; Efflux; Biochemistry; Transporter; Biology; ABCA1; Wild type; Cyclic nucleotide-binding domain; Membrane transport protein; Cell biology; Chemistry; Peptide sequence; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001320169,0.0002057016,0.0001913189,0.00009935224,0.0001364139,0.0001114585,0.0001360424,0.0002853601,0.0005378736],"category_scores_gemma":[0.0001979068,0.00007093797,0.000223903,0.0001185782,0.000137118,0.000153872,0.0001116597,0.0002531518,0.0003743811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001300987,"about_ca_system_score_gemma":0.0001343745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004688364,"about_ca_topic_score_gemma":0.0003852447,"domain_scores_codex":[0.9999359,0.00001583203,0.000006978596,0.00001129437,0.00001908207,0.00001084362],"domain_scores_gemma":[0.9998472,0.00003473753,0.0000470174,0.00001577131,0.00002370688,0.00003158382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004996204,0.00001452213,0.0005809361,0.00001751982,0.00000257102,0.0001179656,0.00001310001,0.0000819116,0.9982908,0.00004823157,0.00001248661,0.0007697932],"study_design_scores_gemma":[0.00002938929,0.0004387672,0.02900444,0.00001019356,0.0000500263,0.003611115,0.00007614843,0.00471077,0.9570859,0.0001617889,0.004809013,0.00001242005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977355,0.0004627898,0.001373034,0.00004645169,0.000006012101,0.00001022282,0.0001349968,0.000007527951,0.0002234123],"genre_scores_gemma":[0.9942243,0.000466398,0.003611637,0.00004731266,0.000008236328,0.00001497379,0.001018342,0.000008266727,0.0006006861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005378736,"threshold_uncertainty_score":0.001799345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01501457724646483,"score_gpt":0.2231677565043718,"score_spread":0.208153179257907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}