{"id":"W1977882272","doi":"10.1529/biophysj.106.097972","title":"Simulation of the Coupling between Nucleotide Binding and Transmembrane Domains in the ATP Binding Cassette Transporter BtuCD","year":2007,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Danmarks Grundforskningsfond","keywords":"ATP-binding cassette transporter; Nucleotide; Transporter; Cytoplasm; Biophysics; Cyclic nucleotide-binding domain; Transmembrane domain; Transmembrane protein; Biochemistry; Biology; Chemistry; Amino acid; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003050338,0.0004364875,0.0009735535,0.0004694356,0.001216038,0.0009989105,0.001288092,0.001982615,0.005882008],"category_scores_gemma":[0.00163714,0.0005349388,0.0006021047,0.0007156453,0.001100927,0.0007322287,0.0005558128,0.00131143,0.0002531182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002705405,"about_ca_system_score_gemma":0.002305795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.05233658,"about_ca_topic_score_gemma":0.0211185,"domain_scores_codex":[0.9998177,0.00003346702,0.000005905782,0.00002511091,0.00003442321,0.00008336001],"domain_scores_gemma":[0.9989657,0.0006037584,0.00005526901,0.00005318718,0.0001262,0.0001958168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0003953197,0.0002312555,0.003317181,0.00007289267,0.00006581649,0.00037368,0.0001542202,0.9819115,0.004050182,0.006571825,0.0009668999,0.001889125],"study_design_scores_gemma":[0.00008724524,0.00005599261,0.0007291813,0.000007317372,0.00001063178,0.00001500016,0.00005657192,0.9976311,0.000543375,0.0005926264,0.0002601509,0.00001081136],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895033,0.0001270231,0.002190668,0.0005277478,0.00004224663,0.00001636684,0.0002931032,0.00008688192,0.007212752],"genre_scores_gemma":[0.9974108,0.00008067669,0.001222602,0.00008280369,0.000008205818,0.00002493995,0.0002304729,0.00002631081,0.0009132148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05233658,"threshold_uncertainty_score":0.1040639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0201103603997417,"score_gpt":0.2778075747009899,"score_spread":0.2576972143012482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}