{"id":"W1977891703","doi":"10.1038/nature09444","title":"The proteasome antechamber maintains substrates in an unfolded state","year":2010,"lang":"en","type":"article","venue":"Nature","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Proteasome; Physics; State (computer science); Chemistry; Biophysics; Biology; Biochemistry; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003323342,0.0001281077,0.00007860798,0.00002480152,0.0001053181,0.00005716841,0.0002691567,0.0007851473,0.00001972554],"category_scores_gemma":[0.00009220845,0.00008826255,0.00004134563,0.00009551349,0.00008309992,0.000005425048,0.00005521724,0.001532973,0.000009808683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005353118,"about_ca_system_score_gemma":0.00007284328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001108003,"about_ca_topic_score_gemma":0.001768268,"domain_scores_codex":[0.9991758,0.00005608398,0.0001229384,0.0002501924,0.0001111779,0.000283754],"domain_scores_gemma":[0.9994187,0.00001000379,0.0000453353,0.000382943,0.00006989158,0.00007310211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008259145,0.00003837624,0.004710255,0.000006089056,0.000007689517,0.00001006182,0.0000583883,0.000001852975,0.990081,0.001101507,0.0003931753,0.003509089],"study_design_scores_gemma":[0.0003792125,0.0001469052,0.01289441,0.000007337521,0.000002248585,0.00002274683,0.00007532415,0.00003491522,0.9315949,0.003532232,0.05112649,0.0001832606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973156,0.000443561,0.000007129847,0.0006114137,0.0002074288,0.0003570596,0.00002624303,0.00001833531,0.00101327],"genre_scores_gemma":[0.9983794,0.00005226691,0.0002401268,0.0003891951,0.0001882315,0.00005286118,0.00005913641,0.00001870198,0.000620074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05848601,"threshold_uncertainty_score":0.6660089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005993505239122324,"score_gpt":0.2584954706920328,"score_spread":0.2525019654529104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}