{"id":"W1977891703","doi":"10.1038/nature09444","title":"The proteasome antechamber maintains substrates in an unfolded state","year":2010,"lang":"en","type":"article","venue":"Nature","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Proteasome; Physics; State (computer science); Chemistry; Biophysics; Biology; Biochemistry; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001095144,0.0006723227,0.0008157445,0.0005633442,0.001038433,0.002236765,0.0007417703,0.0009746955,0.003627837],"category_scores_gemma":[0.000897492,0.0005342998,0.0003988403,0.000296903,0.0006135193,0.002897646,0.001169844,0.00163854,0.004778285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007562692,"about_ca_system_score_gemma":0.0005666221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001306607,"about_ca_topic_score_gemma":0.0002777652,"domain_scores_codex":[0.9995136,0.00004740452,0.00003564276,0.0002011845,0.0001061647,0.00009600574],"domain_scores_gemma":[0.9988564,0.000154972,0.0001599953,0.0003726337,0.0001981188,0.0002577564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001024062,0.0001046951,0.002208491,0.0001525134,0.00004056315,0.00109576,0.000140815,0.0004369159,0.9357787,0.02198293,0.003023648,0.03401084],"study_design_scores_gemma":[0.00004427275,0.0003398172,0.003197333,0.00002096979,0.00003073486,0.001816431,0.00009292203,0.002678606,0.9599943,0.005048786,0.02670085,0.00003485234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8932973,0.01305896,0.06609111,0.00328739,0.001634154,0.00005558777,0.0003959223,0.003085174,0.01909438],"genre_scores_gemma":[0.9605049,0.003254421,0.01295904,0.0006737856,0.0004912292,0.00003370666,0.0005549824,0.0003298863,0.02119803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003627837,"threshold_uncertainty_score":0.01213634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005993505239122324,"score_gpt":0.2584954706920328,"score_spread":0.2525019654529104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}