{"id":"W1977903050","doi":"10.1021/acs.jnatprod.5b00070","title":"Anti-parasitic Guanidine and Pyrimidine Alkaloids from the Marine Sponge <i>Monanchora arbuscula</i>","year":2015,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Natural Sciences and Engineering Research Council of Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; European Social Fund; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Guanidine; Sponge; Pyrimidine; Stereochemistry; Biology; Trypanosoma cruzi; Chemistry; Botany; Biochemistry; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007675968,0.0002538285,0.0003450509,0.00005337535,0.00008308692,0.00006231734,0.0003920696,0.0001131879,0.000009376514],"category_scores_gemma":[0.001270783,0.0001515992,0.00009884466,0.0002333814,0.0001278726,0.00003213941,0.000257645,0.0004816505,0.000004654701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002253308,"about_ca_system_score_gemma":0.0001401742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008342001,"about_ca_topic_score_gemma":0.00002606886,"domain_scores_codex":[0.9984435,0.000114754,0.000418669,0.0003730871,0.0003669477,0.00028303],"domain_scores_gemma":[0.9983191,0.00003264291,0.0003286701,0.0004502379,0.0007126186,0.0001566587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00101955,0.00015523,0.01842778,0.00004493559,0.0003176125,0.0001103561,0.00009960321,0.00003793793,0.859841,0.00008115944,0.1010371,0.01882765],"study_design_scores_gemma":[0.003824618,0.001575695,0.1865229,0.00009171583,0.0003192821,0.001905203,0.0001602163,0.00008125243,0.4950511,0.001189132,0.3084696,0.0008092036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9549158,0.03315295,0.000004081747,0.01021165,0.001308406,0.0001847179,0.000008648602,0.000007590935,0.0002062062],"genre_scores_gemma":[0.9919155,0.001470075,0.001083288,0.0007377499,0.003857552,0.000001053514,0.00006602235,0.00002642289,0.0008422846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3647899,"threshold_uncertainty_score":0.6182036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01403808611907206,"score_gpt":0.2403490461981442,"score_spread":0.2263109600790721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}