{"id":"W1977903050","doi":"10.1021/acs.jnatprod.5b00070","title":"Anti-parasitic Guanidine and Pyrimidine Alkaloids from the Marine Sponge <i>Monanchora arbuscula</i>","year":2015,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Natural Sciences and Engineering Research Council of Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; European Social Fund; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Guanidine; Sponge; Pyrimidine; Stereochemistry; Biology; Trypanosoma cruzi; Chemistry; Botany; Biochemistry; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006763692,0.0003223403,0.000162757,0.0003892211,0.000233711,0.0001680458,0.0001090869,0.000146989,0.0007179257],"category_scores_gemma":[0.0001019969,0.00008332114,0.0001733968,0.0001900297,0.0001479998,0.0001327525,0.0001707052,0.0002097901,0.000193469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001431818,"about_ca_system_score_gemma":0.0002427317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001793736,"about_ca_topic_score_gemma":0.004969561,"domain_scores_codex":[0.9999582,0.000006341065,0.000004722203,0.00000997561,0.00001219087,0.000008633434],"domain_scores_gemma":[0.9999409,0.000008335314,0.00001773162,0.000005055026,0.00001199276,0.00001588325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009380903,0.000007255131,0.0007955552,0.0000897113,0.000008216413,0.00007286775,0.0000201752,0.00002986641,0.994846,0.00001711969,0.00001924477,0.004000206],"study_design_scores_gemma":[0.00004839974,0.001648733,0.1591404,0.00005405657,0.0001090445,0.002458388,0.0001474178,0.0005224104,0.8236766,0.00007308818,0.01209498,0.0000264744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920663,0.003463359,0.001050964,0.00006191635,0.000009827178,0.00003740818,0.0006667979,0.00006057806,0.00258287],"genre_scores_gemma":[0.9925686,0.001566167,0.002719692,0.00008413028,0.00001359575,0.00002432892,0.001394547,0.00001311182,0.001615841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001793736,"threshold_uncertainty_score":0.003566623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01403808611907206,"score_gpt":0.2403490461981442,"score_spread":0.2263109600790721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}