{"id":"W1978004227","doi":"10.1158/1538-7445.am10-216","title":"Abstract 216: Role of Akt isoforms in chemoresistance of human endometrial carcinoma cells","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Kruppel-like factors research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières; Innovation and Economic Development Trois Rivières","funders":"","keywords":"Protein kinase B; AKT2; Cancer research; Gene isoform; Cisplatin; Transfection; Cell culture; XIAP; Biology; Cell growth; Apoptosis; Chemistry; AKT1; Cell biology; Signal transduction; Internal medicine; Medicine; Programmed cell death; Caspase; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001212495,0.0001362714,0.0002754534,0.0003973565,0.00005578836,0.00001814646,0.0007053248,0.0002483704,0.0003149759],"category_scores_gemma":[0.0003755156,0.000126018,0.0001053084,0.0005912557,0.0005053458,0.000008296851,0.0002850191,0.0006032439,0.000007793405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006328057,"about_ca_system_score_gemma":0.0005193149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002578655,"about_ca_topic_score_gemma":0.003047373,"domain_scores_codex":[0.9977827,0.00007978104,0.000388409,0.0004049714,0.0007298792,0.0006142564],"domain_scores_gemma":[0.9985187,0.00008323482,0.0001003503,0.0006634358,0.0004921743,0.0001420888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003658455,0.0002756648,0.03526852,0.000117429,0.00001844089,0.000003759497,0.00008291023,0.000002182952,0.9614802,0.00006619826,0.0006832798,0.001635577],"study_design_scores_gemma":[0.001966223,0.0002402334,0.03602909,0.00002312003,0.000001750012,5.640474e-7,0.0001467387,0.00000288444,0.9590116,0.0001347005,0.002331063,0.0001120572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956837,0.0007240078,0.000001294637,0.00003816637,0.0001166126,0.0003737802,0.00009970117,0.000003226712,0.002959513],"genre_scores_gemma":[0.9988771,0.0001433885,0.00004876508,0.000004081771,0.0002743112,0.0000702082,0.00003215101,0.00003105163,0.0005189282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003193417,"threshold_uncertainty_score":0.5138866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03351290177873132,"score_gpt":0.3789946241851119,"score_spread":0.3454817224063806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}