{"id":"W1978005559","doi":"10.1021/cc050043h","title":"Aza-Amino Acid Scanning of Secondary Structure Suited for Solid-Phase Peptide Synthesis with Fmoc Chemistry and Aza-Amino Acids with Heteroatomic Side Chains","year":2005,"lang":"en","type":"article","venue":"Journal of Combinatorial Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Side chain; Amino acid; Chemistry; Solid-phase synthesis; Combinatorial chemistry; Peptide; Peptide synthesis; Phase (matter); Stereochemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002250538,0.000432767,0.0002254299,0.0001677434,0.0001501758,0.0002195015,0.0001926306,0.0002819502,0.000847569],"category_scores_gemma":[0.0001559192,0.0001542274,0.00025307,0.0001689948,0.0002202655,0.0002008367,0.0001811148,0.0004293451,0.0004704162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002422083,"about_ca_system_score_gemma":0.0001815931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000211258,"about_ca_topic_score_gemma":0.0002769402,"domain_scores_codex":[0.9998478,0.00003187952,0.000009511917,0.0000342293,0.00004478265,0.00003175005],"domain_scores_gemma":[0.9999032,0.00002182156,0.00002953589,0.00001150723,0.00001787091,0.00001604448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002777444,0.000005549413,0.00002334176,0.00002549358,0.000002270901,0.00001947787,0.000006718967,0.00009701632,0.9988675,0.0001100095,0.0000110373,0.0008039327],"study_design_scores_gemma":[0.000007742682,0.00009444625,0.0002442811,0.000001809666,0.000004265261,0.00009988259,0.000002682,0.0004387522,0.997717,0.00003571463,0.001350237,0.000003146173],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9202393,0.003382079,0.07165051,0.00009014294,0.00007513481,0.0002422281,0.000355319,0.0003176668,0.003647687],"genre_scores_gemma":[0.9406632,0.001870563,0.0531141,0.00009356518,0.00002848128,0.0002644429,0.0007175479,0.00006485709,0.003183234],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.000847569,"threshold_uncertainty_score":0.002835453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004777728296345815,"score_gpt":0.2465284044298918,"score_spread":0.241750676133546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}