{"id":"W1978026946","doi":"10.1371/journal.pone.0063189","title":"Mitogen- and Stress-Activated Protein Kinases 1 and 2 Are Required for Maximal Trefoil Factor 1 Induction","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Kruppel-like factors research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Terry Fox Foundation; Strong; CancerCare Manitoba Foundation; Manitoba Health Research Council","keywords":"Cell biology; Kinase; MAPK/ERK pathway; Phosphorylation; Protein kinase A; Biology; Histone H3; Mitogen-activated protein kinase; Regulation of gene expression; Signal transduction; Molecular biology; Histone; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003669549,0.0001365862,0.0001544693,0.0000478321,0.00008063434,0.00005781776,0.00007467216,0.0001615076,0.00004776908],"category_scores_gemma":[0.0002357818,0.0001228583,0.00002512105,0.00004952129,0.00008975212,0.0000156205,0.0000893781,0.00008094695,0.000005058655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001606693,"about_ca_system_score_gemma":0.00002970406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001001733,"about_ca_topic_score_gemma":0.00003135041,"domain_scores_codex":[0.999101,0.00004197431,0.0001237117,0.0003360906,0.0001493299,0.0002478418],"domain_scores_gemma":[0.9994378,0.00001253377,0.00006476838,0.0001951347,0.000174555,0.0001151784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001246281,0.0002240283,0.01147806,0.0001370128,0.0001122997,5.022689e-7,0.00003121109,6.1046e-8,0.9857525,0.000001934776,0.0001622606,0.001975476],"study_design_scores_gemma":[0.0005907061,0.0004268127,0.03065854,0.00005933428,0.00001410888,0.000001312826,0.0001088427,0.00001901118,0.9676766,0.00003794575,0.0002581559,0.0001485786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980642,0.0003186199,0.00001866691,0.0003255507,0.00001893073,0.0009281813,0.0002806394,0.00001735376,0.0000278149],"genre_scores_gemma":[0.9974023,0.00007619676,0.0005079086,0.00001845807,0.0001502032,0.0002993681,0.000203653,0.00002775108,0.001314174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01918047,"threshold_uncertainty_score":0.5010014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06008096821510717,"score_gpt":0.2633903960562241,"score_spread":0.2033094278411169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}