{"id":"W1978072979","doi":"10.1016/j.ymgme.2008.03.013","title":"Human betaine-homocysteine methyltransferase (BHMT) and BHMT2: Common gene sequence variation and functional characterization","year":2008,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institutes of Health; National Institute of General Medical Sciences; Royal College of Physicians and Surgeons of Canada; Mayo Clinic","keywords":"Nonsynonymous substitution; Methyltransferase; Single-nucleotide polymorphism; Genetics; Biology; Gene; Exon; RNA splicing; Intron; Molecular biology; Methylation; Genotype; RNA; Genome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001746027,0.0001580762,0.0002705737,0.0001402453,0.000202525,0.00003377348,0.00002953766,0.0001013806,0.00001762762],"category_scores_gemma":[0.00001661024,0.0001441605,0.00003319566,0.0001410001,0.0001393306,0.00005971513,0.00004505948,0.0001439924,0.000001596351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009603202,"about_ca_system_score_gemma":0.00004235452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000700372,"about_ca_topic_score_gemma":0.000003896822,"domain_scores_codex":[0.9989402,0.00007235549,0.0002129026,0.0003038676,0.0002739806,0.000196654],"domain_scores_gemma":[0.9994575,0.0000115161,0.00003781417,0.0001770488,0.0001241932,0.0001918708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003145292,0.00004627652,0.001973335,0.00004112602,0.00006998757,0.00009231569,0.0002415981,0.000003958374,0.9920139,0.0004525144,0.000005951811,0.005027641],"study_design_scores_gemma":[0.002007877,0.0002009532,0.8307789,0.00001599117,0.0002048288,0.0004196728,0.00001010036,0.001385509,0.1620716,0.0002282119,0.00249073,0.0001856244],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885954,0.005187192,0.005337838,0.0004129983,0.00004767993,0.0003076209,0.00002886902,0.00001933844,0.000063056],"genre_scores_gemma":[0.9940569,0.00387698,0.001049904,0.0004027314,0.0001144168,0.00001529146,0.0002473362,0.00002405664,0.0002123851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8299422,"threshold_uncertainty_score":0.5878693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02993825419292509,"score_gpt":0.2773411362542681,"score_spread":0.247402882061343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}