{"id":"W1978072979","doi":"10.1016/j.ymgme.2008.03.013","title":"Human betaine-homocysteine methyltransferase (BHMT) and BHMT2: Common gene sequence variation and functional characterization","year":2008,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institutes of Health; National Institute of General Medical Sciences; Royal College of Physicians and Surgeons of Canada; Mayo Clinic","keywords":"Nonsynonymous substitution; Methyltransferase; Single-nucleotide polymorphism; Genetics; Biology; Gene; Exon; RNA splicing; Intron; Molecular biology; Methylation; Genotype; RNA; Genome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002511779,0.0003317663,0.0004147135,0.0007254602,0.0002346946,0.000352247,0.0003429175,0.0004526014,0.00152391],"category_scores_gemma":[0.0007091066,0.0001397986,0.0005163011,0.0007124253,0.0002801784,0.0001310153,0.0002603974,0.0004462215,0.0003312928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001982254,"about_ca_system_score_gemma":0.0001651294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001901181,"about_ca_topic_score_gemma":0.001195103,"domain_scores_codex":[0.9997603,0.0000454672,0.00002583991,0.00008139363,0.00005423717,0.00003269406],"domain_scores_gemma":[0.9995875,0.0001505578,0.00006289905,0.00004355677,0.0000551042,0.0001004469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003147215,0.0001812782,0.04852455,0.0001375642,0.0003108081,0.002935361,0.0005382309,0.0004796472,0.919834,0.0008997456,0.0003366235,0.02267495],"study_design_scores_gemma":[0.0003983716,0.001195131,0.6987788,0.00005156098,0.0005730094,0.03036081,0.0003236143,0.003926003,0.2472473,0.00119824,0.01587691,0.00007029361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955249,0.0008294648,0.002038082,0.00005856464,0.00001864178,0.00002008224,0.0007632735,0.00001594861,0.0007310276],"genre_scores_gemma":[0.9955932,0.0003162293,0.001575328,0.00004493365,0.00002660431,0.00001684117,0.001515524,0.00002087975,0.0008903959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001901181,"threshold_uncertainty_score":0.005097985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02993825419292509,"score_gpt":0.2773411362542681,"score_spread":0.247402882061343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}