{"id":"W1978085487","doi":"10.1016/j.reprotox.2013.10.009","title":"Sub-chronic sulforaphane exposure in CD-1 pregnant mice enhances maternal NADPH quinone oxidoreductase 1 (NQO1) activity and mRNA expression of NQO1, glutathione S-transferase, and glutamate-cysteine ligase: Potential implications for fetal protection against toxicant exposure","year":2013,"lang":"en","type":"article","venue":"Reproductive Toxicology","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"GCLC; Sulforaphane; GCLM; Glutathione; Fetus; Endocrinology; Internal medicine; Chemistry; Medicine; Pharmacology; Biology; Pregnancy; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002601075,0.000313367,0.0004510519,0.0001194225,0.0001450159,0.00002596091,0.000159207,0.0002992004,0.000005474149],"category_scores_gemma":[0.0001332341,0.0002953446,0.00008708503,0.0001193232,0.0004655932,0.00004697788,0.0001353485,0.000185565,8.622183e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005875661,"about_ca_system_score_gemma":0.0001189635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001138107,"about_ca_topic_score_gemma":0.0002116827,"domain_scores_codex":[0.9977698,0.0001688855,0.000467932,0.001069015,0.0001006107,0.0004237351],"domain_scores_gemma":[0.9988602,0.00002710918,0.0002874626,0.0004472049,0.0002494919,0.0001285444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008163217,0.000351173,0.001254959,0.0002800008,0.00006995205,0.00000233927,0.0001456771,0.00005062838,0.9907795,0.00001513267,0.00003154783,0.006202807],"study_design_scores_gemma":[0.001621085,0.001842326,0.05258269,0.00009881982,0.00003379912,0.00007892713,0.0001363626,0.00002563141,0.9429394,0.0003287546,0.00003412563,0.0002780931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920326,0.003116969,0.001696006,0.0006583958,0.0001631147,0.002078541,0.0002269761,0.00001749839,0.000009880427],"genre_scores_gemma":[0.9964432,0.001380167,0.0007897994,0.00002280176,0.0003686325,0.0007838144,0.0001269304,0.00003313878,0.00005148867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05132773,"threshold_uncertainty_score":0.9999499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008330691840542534,"score_gpt":0.2344456739466703,"score_spread":0.2261149821061278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}