{"id":"W1978093163","doi":"10.1038/nature01101","title":"Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome","year":2002,"lang":"en","type":"article","venue":"Nature","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":568,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Apoptosome; Cytochrome c; Caspase; Apoptosis; Cell biology; Caspase-9; Biology; Cytochrome; Intrinsic apoptosis; Caspase 3; Mitochondrion; Molecular biology; Programmed cell death; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00036527,0.0005213885,0.0003491189,0.0007442857,0.0004363045,0.0007804571,0.0002852372,0.0004224672,0.002061004],"category_scores_gemma":[0.0003240946,0.0002661316,0.0004764076,0.0004041229,0.0002834052,0.0008366864,0.0004653361,0.00118932,0.001015398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007992382,"about_ca_system_score_gemma":0.0003436161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002422677,"about_ca_topic_score_gemma":0.0003824286,"domain_scores_codex":[0.9996524,0.0000537479,0.00002852347,0.00004115998,0.000111933,0.0001123027],"domain_scores_gemma":[0.9996266,0.00006696138,0.00007998788,0.0000779831,0.00008059694,0.0000678961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000715708,0.00008022489,0.0004383045,0.00007529069,0.00001615921,0.0003535734,0.00003819154,0.00008846479,0.9915614,0.001877912,0.0002801497,0.004474634],"study_design_scores_gemma":[0.0001454328,0.0002200477,0.004895611,0.00001433622,0.00002115309,0.001453849,0.00004751695,0.001372746,0.9853699,0.00113663,0.005310822,0.00001198179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9717308,0.004634438,0.01290248,0.0007216663,0.0002999891,0.00008251077,0.0005366745,0.0005038895,0.00858747],"genre_scores_gemma":[0.9897479,0.001167674,0.002965757,0.0001076428,0.00006119831,0.00005703712,0.00052729,0.00002491373,0.005340526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002061004,"threshold_uncertainty_score":0.006894767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00960868225868911,"score_gpt":0.2249499071776652,"score_spread":0.2153412249189761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}