{"id":"W1978094899","doi":"10.1038/nature09523","title":"The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA","year":2010,"lang":"en","type":"article","venue":"Nature","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2344,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"CRISPR; Plasmid; Biology; Extrachromosomal DNA; Bacteriophage; Trans-activating crRNA; Microbiology; Genetics; DNA; Cas9; Gene; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005845989,0.0005891173,0.0006580342,0.0008039817,0.0003648595,0.0009078066,0.0006175525,0.0009789147,0.001933935],"category_scores_gemma":[0.0006424188,0.0005247947,0.0004432605,0.0003021487,0.0007626878,0.0004037037,0.0006367742,0.001451769,0.001359058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009364336,"about_ca_system_score_gemma":0.0006091491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007032728,"about_ca_topic_score_gemma":0.001299168,"domain_scores_codex":[0.9992203,0.00006851884,0.00004110783,0.0001692639,0.0003749883,0.0001258269],"domain_scores_gemma":[0.9995742,0.0001123993,0.0001098429,0.00006231614,0.00005595911,0.00008513862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000675288,0.0000142769,0.0001684109,0.00006699785,0.00001246209,0.00008305383,0.0000152535,0.0001484062,0.9886573,0.001806758,0.0004106782,0.008548847],"study_design_scores_gemma":[0.000008388493,0.00005291614,0.0007769557,0.000006903971,0.000007835881,0.0003515598,0.0000117284,0.0008834462,0.9880967,0.0005538606,0.009238108,0.00001161868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5977709,0.008665348,0.3463593,0.002031103,0.001199892,0.0003628335,0.001447148,0.006573043,0.03559048],"genre_scores_gemma":[0.8728826,0.002751639,0.09608857,0.0006533097,0.0001153165,0.0001212053,0.001125311,0.0003600766,0.02590193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001933935,"threshold_uncertainty_score":0.006794333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001651782183558306,"score_gpt":0.2428616953103654,"score_spread":0.2412099131268071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}