{"id":"W1978116730","doi":"10.1016/j.febslet.2007.09.013","title":"Suppression of nuclear Wnt signaling leads to stabilization of Rac1 isoforms","year":2007,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"","keywords":"RAC1; Wnt signaling pathway; Nuclear localization sequence; NLS; Cell biology; Nuclear transport; Signal transduction; Regulator; Nuclear export signal; Gene isoform; GTPase; Function (biology); Biology; Chemistry; Biochemistry; Cell nucleus; Gene; Cytoplasm","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002737127,0.00009217584,0.0001166636,0.0000593619,0.00003215469,0.000005304554,0.0001397111,0.00007618966,0.00006893395],"category_scores_gemma":[0.00003673579,0.00008282295,0.00005619632,0.0001090179,0.00004552319,0.000004352362,0.00006196459,0.00004087943,0.000004544532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000015448,"about_ca_system_score_gemma":0.00002030367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008401742,"about_ca_topic_score_gemma":0.000003402749,"domain_scores_codex":[0.9992128,0.0000148391,0.0002617757,0.0001752702,0.0001612631,0.0001740689],"domain_scores_gemma":[0.9996153,0.00001073689,0.000106332,0.000149052,0.00007286044,0.00004575858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000171612,0.00001984523,0.006009343,0.00003266509,0.00001621275,6.991683e-7,0.0002802893,0.0007285514,0.9881933,0.00001763011,0.003820875,0.0007090239],"study_design_scores_gemma":[0.0002427144,0.0001043548,0.003480886,0.00004580437,0.000008081271,8.495359e-7,0.00008020669,0.000007667172,0.9901969,0.000007539958,0.005712974,0.0001120465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921811,0.00006489539,0.007007471,0.0002936224,0.0001534744,0.0001138837,0.000003810113,0.000007670629,0.0001741145],"genre_scores_gemma":[0.9962485,0.000009965862,0.002540974,0.0009694197,0.00009676463,0.000002586884,0.00004179332,0.00001855176,0.00007146115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004466497,"threshold_uncertainty_score":0.3377421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007892310381598744,"score_gpt":0.2396230282513585,"score_spread":0.2317307178697597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}