{"id":"W1978118879","doi":"10.1016/j.toxlet.2005.08.006","title":"Role for mitogen-activated protein kinases in phenobarbital-induced expression of cytochrome P450 2B in primary cultures of rat hepatocytes","year":2005,"lang":"en","type":"article","venue":"Toxicology Letters","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Ligue Contre le Cancer","keywords":"p38 mitogen-activated protein kinases; Kinase; MAPK/ERK pathway; Enhancer; Protein kinase A; Molecular biology; Cell biology; Mitogen-activated protein kinase; Biology; Signal transduction; Chemistry; Gene expression; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002813286,0.0003153019,0.0003386609,0.000410733,0.0003613113,0.0004095875,0.0001489185,0.0002047184,0.001763194],"category_scores_gemma":[0.0001948993,0.000271739,0.000473297,0.0002647785,0.0002472661,0.0003201881,0.0002413738,0.0006888306,0.0007480847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004473383,"about_ca_system_score_gemma":0.0002969523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001531539,"about_ca_topic_score_gemma":0.003157357,"domain_scores_codex":[0.9997856,0.00005572291,0.00002259583,0.00003128915,0.0000438998,0.00006088877],"domain_scores_gemma":[0.9997748,0.00009116065,0.00002110141,0.00003813574,0.00003351477,0.00004139832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003267545,0.00003235493,0.0001906417,0.00003060322,0.000004602421,0.00006045388,0.00002208132,0.00004033669,0.9985657,0.00009135396,0.0000442026,0.000590911],"study_design_scores_gemma":[0.0000264312,0.0002275815,0.007332186,0.00000565395,0.00001719993,0.0001734086,0.00006101988,0.0006485978,0.9901465,0.00005511687,0.001302275,0.000003970092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853604,0.00524204,0.004845735,0.0003764922,0.0001142179,0.0000519501,0.001277296,0.000084704,0.002647182],"genre_scores_gemma":[0.9881373,0.002234273,0.003549566,0.00009279122,0.00004990653,0.0000870592,0.001781354,0.00002832875,0.00403927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001763194,"threshold_uncertainty_score":0.005898476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05281194561271687,"score_gpt":0.3764641498454944,"score_spread":0.3236522042327775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}